Milrinone Administered Before Ischemia or Just After Reperfusion, Attenuates Myocardial Stunning in Anesthetized Swine
Milrinone Administered Before Ischemia or Just After Reperfusion, Attenuates Myocardial Stunning in Anesthetized Swine
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DOI：
10.1007/s10557-006-0166-7
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发表时间：
2006-11
影响因子：
3.4
通讯作者：
Tadasuke Use;T. Makita;H. Ureshino;Sungsam Cho;O. Yoshitomi;Daiji Akiyama;M. Oshibuchi;T. Hara;K. Sumikawa
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文献类型：
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作者：
Tadasuke Use;T. Makita;H. Ureshino;Sungsam Cho;O. Yoshitomi;Daiji Akiyama;M. Oshibuchi;T. Hara;K. Sumikawa
PurposeWe assessed dose or timing effect of milrinone administered against myocardial stunning in 37 anesthesized open-chest swines.MethodsAll猪进行了12分钟的缺血再灌注产生心肌顿抑。A组（n= 12）缺血前、后均给予生理盐水代替米力农。B组（n= 9）和C组（n= 9）分别以5 μg/kg/min的速度静脉注射米力农10 min，然后以0.5 μg/kg/min的速度静脉注射米力农10 min，10 μg/kg/min的速度静脉注射米力农10 min，然后以1 μg/kg/min的速度静脉注射米力农10 min，直至冠状动脉阻断前30 min。D组（n= 7）于再灌注后1 min开始给予与B组相同剂量的米力农。心肌收缩力进行了评估，通过百分比段缩短（%SS）。结果五只猪在A组和两个猪在组B和C各自有心室颤动或心动过速再灌注后，因此被排除在进一步的分析。B、C和D组再灌注后90 min %SS较基线的百分比变化分别为78 ± 9%、82 ± 13%和79 ± 7%，显著高于A组（43 ± 13%）。
PurposeWe assessed the dose or timing effect of milrinone administered against myocardial stunning in 37 anesthetized open-chest swine.MethodsAll swine were subjected to 12-min ischemia followed by reperfusion to produce myocardial stunning. Group A (n= 12) received saline in place of milrinone both before and after ischemia. Group B (n= 9) and C (n= 9) received intravenous milrinone at a rate of 5 μg/kg/min for 10 min followed by 0.5 μg/kg/min for 10 min and 10 μg/kg/min for 10 min followed by 1 μg/kg/min for 10 min, respectively, until 30 min before coronary occlusion. Group D (n= 7) received the same dose of milrinone as group B starting 1 min after reperfusion. Myocardial contractility was assessed by percentage segment shortening (%SS).ResultsFive swine in group A and two swine in groups B and C each had ventricular fibrillation or tachycardia after reperfusion, and were thus excluded from further analysis. The percentage changes of %SS from the baseline 90 min after reperfusion in groups B, C, and D were 78 ± 9%, 82 ± 13%, and 79 ± 7%, respectively, which were significantly higher than those in group A (43 ± 13%).ConclusionWe conclude that milrinone administered before ischemia or just after reperfusion attenuates myocardial stunning.