Quantitative determination of antibody to capsular polysaccharide in infection with type III strains of group B Streptococcus.
Quantitative determination of antibody to capsular polysaccharide in infection with type III strains of group B Streptococcus.
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B 族链球菌 III 型菌株感染中荚膜多糖抗体的定量测定。
DOI：
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发表时间：
1977
影响因子：
15.9
通讯作者：
D. K. Goroff
中科院分区：
文献类型：
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作者：
Carol J. Baker;Dennis L. Kasper;Ira B. Tager;Abel Paredes;Susan Alpert;William M. McCormack;D. K. Goroff
应用放射性抗原结合定量分析法，对31例婴儿和4例成人血清中B组链球菌Ⅲ型侵入性感染后抗体的产生进行了研究。在发生临床疾病的患者的急性血清中始终发现低浓度的抗体。虽然产后脓毒症的成人和婴儿骨或关节感染统一表现出显着上升，血清抗体浓度恢复后，低得多的抗体水平检测到从脑膜炎或脓毒症的婴儿恢复期血清。从阴道培养的新生儿未能发展出有症状的疾病的B组链球菌III型菌株的43名产妇血清中的抗体浓度中位数显着大于29名侵入性III型B组链球菌感染的婴儿的母亲血清中的抗体浓度。配对的母亲和脐带血清的研究表明，在母亲的血清中的抗体浓度和在她的新生儿之间的显着相关性。
The development of antibody in response to invasive infection with type III strains of group B Streptococcus was studied in sera from 31 infants and 4 adults by means of a quantitative radioactive antigen-binding assay. Low concentrations of antibody were consistently found in the acute sera of patients who developed clinical illness. Although adults with puerperal sepsis and infants with bone or joint infection uniformly demonstrated significant rises in serum antibody concentration after recovery, much lower levels of antibody were detected in convalescent sera from infants recovering from meningitis or sepsis. The median antibody concentration in sera from 43 parturients with type III strains of group B Streptococcus isolated from vaginal cultures whose neonates failed to develop symptomatic disease was significantly greater than that in sera from 29 mothers of infants with invasive, type III, group B streptococcal infection. Study of paired maternal and cord sera demonstrated a significant correlation between the antibody concentration in a mother's serum and that in her neonate.