Four new quassinoids from the roots of Eurycoma longifolia Jack
Four new quassinoids from the roots of Eurycoma longifolia Jack
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来自东革阿里根的四种新苦木素
DOI：
10.1016/j.fitote.2013.10.009
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发表时间：
2014-01-01
期刊：
影响因子：
3.4
通讯作者：
Li, Xian
中科院分区：
文献类型：
--
作者：
Meng, Dali;Li, Xin;Li, Xian
从东革阿里（Eurycoma longifolia）的根中分离得到7个化合物，并通过沿着核磁共振和X射线单晶衍射等手段对其结构进行了表征。其中鉴定了4个新的苦木素类化合物，其中3个为非对映异构体。评价化合物1-7对HT-29、MCF-7、LOVO、BGC-823、MGC-803、HepG 2、HeLa和A549癌细胞系的细胞毒性。化合物2和5对MCF-7、MGC-803癌细胞系分别表现出24.9 μ M、11.8 μ M和44.1 μ M、14.1 μ M的最低IC 50值，而化合物6对所有选择的癌细胞系表现出中等的细胞毒性。(C)2013爱思唯尔有限公司版权所有。
Seven compounds were isolated from the roots of Eurycoma longifolia, and characterized by comprehensive analysis of 1D and 2D NMR experiments along with single crystal X-ray diffraction. Among them, four new quassinoids were identified and three of them were diastereomers for each other. Compounds 1-7 were evaluated for cytotoxicities against HT-29, MCF-7, LOVO, BGC-823, MGC-803, HepG2, HeLa, and A549 cancer cell lines. Compounds 2 and 5 exhibited the lowest IC50 values of 24.9 mu M, 11.8 mu M, and 44.1 mu M, 14.1 mu M towards MCF-7, MGC-803 cancer cell lines, respectively, while compound 6 exhibited moderate cytotoxicity towards all the selected cancer cell lines. (C) 2013 Elsevier B.V. All rights reserved.