Spontaneous brain activity in combat related PTSD
Spontaneous brain activity in combat related PTSD
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DOI：
10.1016/j.neulet.2013.04.032
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发表时间：
2013-06
影响因子：
2.5
通讯作者：
Xiaodan Yan;Adam D. Brown;M. Lazar;V. Cressman;Clare Henn-Haase;T. Neylan;A. Shalev;O. Wolkowitz;S. Hamilton;R. Yehuda;D. Sodickson;M. Weiner;C. Marmar
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文献类型：
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作者：
Xiaodan Yan;Adam D. Brown;M. Lazar;V. Cressman;Clare Henn-Haase;T. Neylan;A. Shalev;O. Wolkowitz;S. Hamilton;R. Yehuda;D. Sodickson;M. Weiner;C. Marmar
创伤后应激障碍（PTSD）是一种常见的精神疾病，尤其是在战斗退伍军人中。现有的功能性神经影像学研究提供了重要的见解创伤后应激障碍的神经机制，使用各种实验范式，涉及创伤回忆或其他形式的情绪激发。然而，目前尚不清楚异常的大脑活动是特定于与实验任务相关的心理过程，还是反映了不同大脑状态的一般模式。因此，研究内在的自发性脑活动，而不受外部任务的影响，可能会提供有价值的替代观点，以进一步了解创伤后应激障碍的神经特征。本研究评估了有或没有创伤后应激障碍的美国男性退伍军人自发脑活动的程度，两组在年龄，性别和种族上相匹配。低频波动幅度（ALFF），一种数据驱动的分析方法，计算每个体素的静息状态fMRI数据来测量自发脑活动的幅度。结果显示，PTSD受试者表现出杏仁核、腹侧前扣带皮层、额叶皮层和眶额叶皮层的自发活动增加，楔前叶、背外侧前额叶皮层和丘脑的自发活动减少。在PTSD组中，丘脑、楔前叶和背外侧前额叶皮层的自发活动幅度较大，与较低的再体验症状有关。将我们的结果与以前的功能性神经影像学结果进行比较，杏仁核和前额叶的活动增加以及丘脑的活动减少是情绪激发状态和静息状态下的一致模式。
Posttraumatic stress disorder (PTSD) is a prevalent psychiatric disorder, especially in combat veterans. Existing functional neuroimaging studies have provided important insights into the neural mechanisms of PTSD using various experimental paradigms involving trauma recollection or other forms of emotion provocation. However it is not clear whether the abnormal brain activity is specific to the mental processes related to the experimental tasks or reflects general patterns across different brain states. Thus, studying intrinsic spontaneous brain activity without the influence of external tasks may provide valuable alternative perspectives to further understand the neural characteristics of PTSD. The present study evaluated the magnitudes of spontaneous brain activity of male US veterans with or without PTSD, with the two groups matched on age, gender, and ethnicity. Amplitudes of low frequency fluctuation (ALFF), a data driven analysis method, were calculated on each voxel of the resting state fMRI data to measure the magnitudes of spontaneous brain activity. Results revealed that PTSD subjects showed increased spontaneous activity in the amygdala, ventral anterior cingulate cortex, insula, and orbital frontal cortex, as well as decreased spontaneous activity in the precuneus, dorsal lateral prefrontal cortex and thalamus. Within the PTSD group, larger magnitudes of spontaneous activity in the thalamus, precuneus and dorsal lateral prefrontal cortex were associated with lower re-experiencing symptoms. Comparing our results with previous functional neuroimaging findings, increased activity of the amygdala and anterior insula and decreased activity of the thalamus are consistent patterns across emotion provocation states and the resting state.