The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis.
The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis.
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炎性小体是一种多蛋白复合物，其介导半胱天冬酶-1的活化，半胱天冬酶-1促进促炎细胞因子IL-1β和IL-18的分泌以及焦亡，一种由细菌病原体诱导的细胞死亡形式。Nod样受体家族的成员包括NLRP 1、NLRP 3和NLRC 4以及接头ASC，它们通过将微生物和内源性危险信号与半胱天冬酶-1激活相联系而成为炎性小体的关键组分。几种疾病与半胱天冬酶-1和IL-1β分泌的失调激活有关。因此，了解炎性体途径可以提供深入了解疾病的发病机制，可能作为潜在的治疗干预的目标。
The inflammasome is a multi-protein complex that mediates activation of caspase-1 which promotes the secretion of the proinflammatory cytokines IL-1β and IL-18 as well as pyroptosis, a form of cell death induced by bacterial pathogens. Members of the Nod-like receptor family including NLRP1, NLRP3 and NLRC4 and the adaptor ASC are critical components of the inflammasome by linking microbial and endogenous danger signals to caspase-1 activation. Several diseases are associated with the dysregulated activation of caspase-1 and IL-1β secretion. Thus, understanding of inflammasome pathways may provide insights into disease pathogenesis that might serve as potential targets for therapeutic intervention.
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DOI：
10.1016/s0006-291x(03)00221-3
发表时间：
2003-03-14
影响因子：
3.1
作者：
Dowds, TA;Masumoto, J;Núñez, G
通讯作者：
Núñez, G
影响因子：
30.5
作者：
Buerckstuemmer, Tilmann;Baumann, Christoph;Superti-Furga, Giulio
通讯作者：
Superti-Furga, Giulio
影响因子：
5.4
作者：
Franchi, Luigi;Stoolman, Joshua;Nunez, Gabriel
通讯作者：
Nunez, Gabriel
影响因子：
30.5
作者：
Franchi, Luigi;Amer, Amal;Nunez, Gabriel
通讯作者：
Nunez, Gabriel
影响因子：
5.4
作者：
Franchi, Luigi;Nunez, Gabriel
通讯作者：
Nunez, Gabriel