Lineage infidelity in acute leukemia.
Lineage infidelity in acute leukemia.
复制标题
急性白血病中的血统不忠。
作者：
Lj Smith;Lj Smith;J. Curtis;J. Curtis;H. Messner;H. Messner;J. Senn;J. Senn;H. Furthmayr;H. Furthmayr;E. McCulloch;E. McCulloch
使用针对谱系特异性分化标记物的抗体对来自 20 名急性白血病患者（13 名诊断为骨髓母细胞，7 名使用 FAB 分类，诊断为淋巴母细胞）的母细胞进行了研究。表型发现通常与临床诊断一致。然而，也遇到过个别母细胞具有一种谱系的细胞质标记和不同谱系的表面标记（谱系不忠）的例子。遇到了六个骨髓内（同一细胞中两种不同的骨髓谱系）的例子和三个谱系间不忠的例子（同一母细胞中的骨髓和淋巴标记物）。在由正常骨髓细胞、移植后再生的骨髓或源自培养物骨髓的多谱系集落组成的对照材料中未发现双重标记细胞。观察到与血统不忠和缓解诱导失败相关的显着趋势。这些数据被解释为白血病基因表达异常的支持。
Blast cells from 20 patients with acute leukemia (13 diagnosed myeloblastic and 7 as lymphoblastic, using the FAB classification) were studied using antibodies to lineage-specific differentiation markers. The phenotypic findings were usually consistent with the clinical diagnosis. However, examples were encountered where individual blast cells had a cytoplasmic marker of one lineage and a surface marker of a different lineage (lineage infidelity). Six examples of intramyeloid (two different myeloid lineages in the same cell) and three examples of interlineage infidelity (myeloid and lymphoid markers in the same blast cell) were encountered. No doubly marked cells were found in control material consisting of normal marrow cells, marrow regenerating after transplantation, or multilineage colonies derived from marrow in culture. A significant trend was observed relating the presence of lineage infidelity and failure of remission-induction. The data are interpreted as support for abnormal gene expression in leukemia.
OKM 1 阳性淋巴细胞群的表型异质性：OKM1 单克隆抗体与抑制/细胞毒性 T 细胞群的子集的反应性。
影响因子：
4.3
作者：
Ceuppens,JL;Gualde,N;Goodwin,JS
通讯作者：
Goodwin,JS
DOI：
10.1073/pnas.77.11.6764
发表时间：
1980
影响因子：
11.1
作者：
Ugolini,V;Nunez,G;Smith,RG;Stastny,P;Capra,JD
通讯作者：
Capra,JD
通过单克隆抗体鉴定人单核细胞上的抗原。
DOI：
--
发表时间：
1981
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Todd3rd,RF;Nadler,LM;Schlossman,SF
通讯作者：
Schlossman,SF