MR myocardial perfusion Imaging with k-space and time broad-use linear acquisition speed-up technique: Feasibility study
MR myocardial perfusion Imaging with k-space and time broad-use linear acquisition speed-up technique: Feasibility study
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DOI：
10.1148/radiol.2453061701
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发表时间：
2007-12-01
期刊：
影响因子：
19.7
通讯作者：
Nagel, Eike
中科院分区：
文献类型：
--
作者：
Gebker, Rolf;Jahnke, Cosima;Nagel, Eike
本研究的目的是前瞻性评估心血管磁共振 (MR) k 空间和时间 (k-t) 广泛使用的线性采集加速技术 (BLAST) 加速灌注序列用于描述临床相关冠状动脉疾病 (CAD) 的诊断准确性，并使用冠状动脉造影作为参考标准。当地伦理委员会批准了这项研究，并获得了 40 名计划进行冠状动脉导管插入术的患者（28 名男性，12 名女性；平均年龄，61 岁 +/- 8 [标准差]）的知情同意书。应用净 k-t 加速因子为 3.8 的平衡稳态自由进动脉冲序列 (2.6 x 2.6 x 10 mm)（重复时间毫秒/回波时间毫秒，3.2/1.6；翻转角，50）。通过使用节段性心肌上坡、峰值增强及其各自的比率，对心肌中获得的灌注图像进行可视化分析和信号-时间曲线的定量分析。视觉分析显示，在检测管腔狭窄至少 50% 的冠状动脉狭窄时，敏感性、特异性和诊断准确性分别为 86%、78% 和 83%。对于应用的所有灌注指数，可以显示缺血段和远端段之间的显着（P < .05）变化。使用心肌灌注成像和 k-t BLAST 加速数据采集对于识别严重 CAD 患者（冠状动脉狭窄 >= 50%）是可行的。
The purpose of this study was to prospectively evaluate the diagnostic accuracy of a cardiovascular magnetic resonance (MR) k-space and time (k-t) broad-use linear acquisition speed-up technique (BLAST) accelerated perfusion sequence for depicting clinically relevant coronary artery disease (CAD), with use of coronary angiography as the reference standard. The local ethics committee approved this study, and informed consent was obtained from 40 patients (28 men, 12 women; mean age, 61 years +/- 8 [standard deviation]) scheduled for coronary catheterization. A balanced steady-state free precession pulse sequence (2.6 x 2.6 x 10 mm) with a net k-t acceleration factor of 3.8 (repetition time msec/echo time msec, 3.2/1.6; flip angle, 50) was applied. Visual analysis of perfusion images and quantitative analysis of signal-time curves obtained in the myocardium were performed by using segmental myocardial upslope, peak enhancement, and their respective ratios. Visual analysis revealed sensitivity, specificity, and diagnostic accuracy of 86%, 78%, and 83%, respectively, in the detection of coronary stenoses with at least 50% luminal narrowing. Significant (P < .05) changes between ischemic and remote segments could be shown for all perfusion indexes applied. Use of myocardial perfusion imaging with k-t BLAST for accelerated data acquisition is feasible in the identification of patients with substantial CAD (coronary stenosis >= 50%).