CONSERVATION OF THE DUCHENNE MUSCULAR-DYSTROPHY GENE IN MICE AND HUMANS
CONSERVATION OF THE DUCHENNE MUSCULAR-DYSTROPHY GENE IN MICE AND HUMANS
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DOI：
10.1126/science.3659917
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发表时间：
1987-10-16
期刊：
影响因子：
56.9
通讯作者：
KUNKEL, LM
中科院分区：
文献类型：
--
作者：
HOFFMAN, EP;MONACO, AP;KUNKEL, LM
对来自人类胎儿骨骼肌和成年小鼠心脏的杜氏肌营养不良 (DMD) 基因转录本的一部分进行了测序，约占 14 kb DMD 转录本总量的 25%。这两个物种的核酸和预测的氨基酸序列几乎 90% 同源。从 DMD 基因的这一部分预测的氨基酸序列表明该蛋白质产物可能在肌肉中发挥结构作用，但信使 RNA 的丰度和组织分布表明 DMD 蛋白质不是星云蛋白。
A portion of the Duchenne muscular dystrophy (DMD) gene transcript from human fetal skeletal muscle and mouse adult heart was sequenced, representing approximately 25 percent of the total, 14-kb DMD transcript. The nucleic acid and predicted amino acid sequences from the two species are nearly 90 percent homologous. The amino acid sequence that is predicted from this portion of the DMD gene indicates that the protein product might serve a structural role in muscle, but the abundance and tissue distribution of the messenger RNA suggests that the DMD protein is not nebulin.