Effect of maternal bone lead on length and head circumference of newborns and 1-month-old infants
Effect of maternal bone lead on length and head circumference of newborns and 1-month-old infants
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DOI：
10.1080/00039890209601441
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发表时间：
2002-09-01
期刊：
影响因子：
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通讯作者：
Hu, H
中科院分区：
文献类型：
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作者：
Hernandez-Avila, M;Peterson, KE;Hu, H
作者评估了223对母婴出生时母体骨铅储存对人体测量的影响。参与者是在1994年4月至11月间招募的。在分娩后的最初12小时内收集人体测量数据。分娩后1个月获取产妇信息。用体内k -x射线荧光测定胫骨（皮质骨）和髌骨（小梁骨）的骨铅负荷。作者将人体测量数据转化为一个有序的5类量表，并利用有序logistic回归模型评估测量数据与其他因素的相关性。胫骨和髌骨的平均骨铅含量分别为9.8杯/克骨矿物质和14.4杯/克骨矿物质。新生儿的出生长度随着胫骨铅含量的增加而减少。与胫骨铅分布的下五分位数的妇女相比，上五分位数的妇女生下低出生长度新生儿的风险增加了79%（优势比= 1.79；95%可信区间= 1.10,3.22）。作者根据出生体重进行了调整，这种影响有所减弱，但仍然很重要。髌骨铅与低头围评分风险呈正相关；这个分数不受出生体重的影响。作者估计每杯铅/克骨矿物质增加的风险为1.02（95%置信区间= 1.01,1.04 /杯铅/克骨矿物质）。在作者调整了出生体重和头围的其他重要决定因素后，比值比没有显著变化。
The authors evaluated the effects that maternal bone lead stores have in anthropometry at birth in 223 mother-infant pairs. The participants were recruited between April and November 1994. Anthropometric data were collected within the first 12 hr following delivery. Maternal information was obtained 1 mo after delivery occurred. Bone lead burden was determined with in-vivo K-x-ray fluorescence of the tibia (cortical bone) and the patella (trabecular bone). The authors transformed anthropometric measurements to an ordinal 5-category scale, and the association of measurements with other factors was evaluated with ordinal logistic-regression models. Mean bone lead levels were 9.8 mug/gm bone mineral and 14.4 mug/gm bone mineral for the tibia and patella, respectively. Birth length of newborns decreased as tibia lead levels increased. Compared with women in the lower quintiles of the distribution of tibia lead, those in the upper quintile had a 79% increase in risk of having a lower birth length newborn (odds ratio = 1.79; 95% confidence interval = 1.10, 3.22). The authors adjusted by birth weight, and the effect was attenuated-but nonetheless significant. Patella lead was positively and significantly related to the risk of a low head circumference score; this score remained unaffected by inclusion of birth weight. The authors estimated the increased risk to be 1.02 per mug lead/gm bone mineral (95% confidence interval = 1.01, 1.04 per mug lead/gm bone mineral). Odds ratios did not vary substantially after the authors adjusted for birth weight and other important determinants of head circumference.