Cloning and characterization of a novel transcription factor involved in cellular proliferation arrest: PATF
Cloning and characterization of a novel transcription factor involved in cellular proliferation arrest: PATF
复制标题
参与细胞增殖停滞的新型转录因子的克隆和表征：PATF
作者：
P. Crisanti;G. Raguénez;C. Blancher;Bertrand Néron;A. Mamoune;B. Omri
细胞周期退出涉及几个转录因子，如E2Fs成员，在细胞生长控制中发挥关键作用。在这里，我们描述了一种新的推定的bZIP转录因子从视网膜中分离出来，并参与在终末分化的神经元增殖阻滞：PATF（增殖阻滞转录因子）。我们发现PATF与E2F4蛋白相关，并与E2F共有位点相互作用。PATF表达随着静止状态的建立而增加。此外，像E2F4一样，核PATF定位取决于细胞生长停滞。使用逆转录病毒反义策略，PATF量的减少导致神经视网膜细胞有丝分裂。我们的研究结果表明，PATF可能是一个新的分子信号参与最终的神经细胞周期退出。
Cell cycle withdrawal involves several transcription factors such as E2Fs members that play a key role in cell growth control. Here we describe a novel putative bZIP transcription factor isolated from the retina and involved in neuronal proliferation arrest at the terminal differentiation: PATF (Proliferation Arrest Transcription Factor). We show that PATF associates with E2F4 protein and interacts with the E2F consensus site. PATF expression increases with establishment of quiescent state. Furthermore, the nuclear PATF localization like E2F4, depends on cell growth arrest. The decrease of PATF amount, using a retroviral antisense strategy, results in pursued neuroretina cell mitosis. Our results indicate that PATF could be a new molecular signal implicated in the final neuronal cell cycle withdrawal.
p27Kip1调控哺乳动物视网膜中晚期多能祖细胞的细胞周期退出
影响因子：
2.7
作者：
Levine, EM;Close, J;Reh, TA
通讯作者：
Reh, TA