Differential Effects of Injury Severity on Cognition and Cellular Pathology after Contusive Brain Trauma in the Immature Rat
Differential Effects of Injury Severity on Cognition and Cellular Pathology after Contusive Brain Trauma in the Immature Rat
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DOI：
10.1089/neu.2010.1639
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发表时间：
2011-02-01
影响因子：
4.2
通讯作者：
Raghupathi, Ramesh
中科院分区：
文献类型：
--
作者：
Huh, Jimmy W.;Widing, Ashley G.;Raghupathi, Ramesh
Although diffuse brain damage has been suggested to be the predominant predictor of neurological morbidity following closed head injury in infants and children, the presence of contusions also predicts long-term neurobehavioral dysfunction. Contusive brain trauma in the 17-day-old rat resulted in neurodegeneration and caspase activation in the cortex at 1 day, and in the thalamus at 3 days post-injury, and to a greater extent following a deeper impact. Cortical tissue loss in the 4-mm impact group was significantly greater than that in the 3-mm impact group (p
