Amino Acid N−Carboxy Anhydrides with High Polymerizability in the Solid State
Amino Acid N−Carboxy Anhydrides with High Polymerizability in the Solid State
复制标题
固态下具有高聚合性的氨基酸 N−羧酸酐
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
H. Kanazawa
中科院分区：
文献类型：
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作者：
H. Kanazawa
摘要氨基酸N-羧酸酐在正己烷和丁胺中进行固相聚合。L-亮氨酸NCA、L-苯丙氨酸NCA、β-苄基-L-天冬氨酸NCA和DL-苯丙氨酸NCA在固态下的聚合性比在溶液中高。发现L-亮氨酸NCA和L-苯丙氨酸NCA在晶体中主要沿着一定的方向聚合。晶体结构，以确定在固态下的高反应性被认为是一个三明治结构：五元环层和侧链层的交替排列，和优选的分子排列的聚合物构象的形成。
Abstract Solid-state polymerization of amino acid N−carboxy anhydrides was carried out in hexane with butylamine. L-Leucine NCA, L-phcnylalanine NCA, β-benzyl-L-aspartate NCA and DL-phenylalanine NCA gave high polymerizability in the solid state, compared with the reaction in the solution. L-Leucine NCA and L-phenylalanine NCA were found to polymerize mainly along a definite direction in the crystal. The crystal structure to determine the high reactivity in the solid state were considered; a sandwich structure: the alternative alignment of the five-membered ring layers and the side chain layers, and the molecular arrangement preferable for the formation of the polymer conformation.