Lipid and lipoprotein cardiovascular risk factor changes during normal pregnancy in Africans
Lipid and lipoprotein cardiovascular risk factor changes during normal pregnancy in Africans
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DOI：
10.1016/s0301-2115(98)00210-3
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发表时间：
1999-01-01
期刊：
影响因子：
--
通讯作者：
Analike, R
中科院分区：
文献类型：
--
作者：
Ahaneku, JE;Adinma, JI;Analike, R
目的：该研究旨在确定怀孕如何影响生活在非洲一个典型郊区商业社区的妇女的脂质和脂蛋白谱，并强调这种变化的后果。研究设计：对27名非洲孕妇和17名相同年龄和人口统计资料的非孕妇进行脂质和脂蛋白水平和冠心病（CHD）风险预测指数[高密度脂蛋白-胆固醇(HDLC)/总胆固醇（TC）]的评估。结果：孕妇总胆固醇和低密度脂蛋白胆固醇（LDLC）水平升高，HDLC水平和HDLC/TC比值降低。结论：这些发现表明，非洲妇女在正常妊娠期间更容易发生高脂血症。孕妇体内脂质和脂蛋白的不良变化对胎儿发育和福利的影响有待进一步研究。总的来说，这些结果增加了我们对可能导致非洲妇女脂质和脂蛋白水平异常的众多因素的理解和认识。1999爱思唯尔科学爱尔兰有限公司版权所有。
Objectives: The study was designed to determine how pregnancy affects lipid and lipoprotein profiles among women living in a typical suburban commercial community in Africa, and to highlight the consequences of such changes. Study Design: Lipid and lipoprotein levels and coronary heart disease (CHD) risk predictor index [High density lipoprotein-cholesterol (HDLC)/Total cholesterol (TC)] were evaluated in 27 African pregnant and 17 non-pregnant women of the same age and demographic profiles. Results: Total cholesterol and low density lipoprotein-cholesterol (LDLC) levels increased, while HDLC level and HDLC/TC ratio decreased in the pregnant women. Conclusions: These findings suggest that African women are more prone to hyperlipidemia during normal pregnancy. The consequences of the adverse lipid and lipoprotein changes as seen in the pregnant women, on the fetal development and welfare should be explored in further studies. In general, these results have added to our understanding and knowledge of the numerous factors that could cause abnormal lipid and lipoprotein levels in African women. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.