Noninvasive MRI assessment of intracranial compliance in idiopathic normal pressure hydrocephalus
Noninvasive MRI assessment of intracranial compliance in idiopathic normal pressure hydrocephalus
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DOI：
10.1002/jmri.20999
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发表时间：
2007-08-01
影响因子：
4.4
通讯作者：
Luechinger, Roger
中科院分区：
文献类型：
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作者：
Miyati, Tosiaki;Mase, Mitsuhito;Luechinger, Roger
目的：为了评估特发性正常压力脑积水（I-NPH）患者颅内系统的状态和动力学，我们使用磁共振成像（MRI）测定颅内顺应性。材料和方法：颅内顺应性指数（ICCI），其定义为颅内容积变化峰-峰（ICVCp-p）与脑脊液（CSF）压力梯度峰-峰（PG（p-p））的比值在心动周期期间，从用相位对比（PC）电影MRI测量的净经颅血液和CSF流量获得。在I-NPH患者（N = 7）、脑萎缩或无症状心室扩张（VD）患者（N = 6）和健康志愿者（对照组; N = 11）中测定ICCI。结果：I-NPH组的ICCI明显低于对照组和VD组，而对照组和VD组之间无差异。ICVCp-p也低于对照组和VD组。然而，未发现组间PGp-p存在显著差异。结论：MRI颅内顺应性分析可无创性地获得I-NPH颅内生物力学的详细信息，有助于I-NPH的诊断。
Purpose: To assess the state and dynamics of the intracranial system in idiopathic normal-pressure hydrocephalus (I-NPH), we determined intracranial compliance using magnetic resonance imaging (MRI).Materials and Methods: The intracranial compliance index (ICCI), which was defined as the ratio of the peak-to-peak intracranial volume change (ICVCp-p) to the peak-to-peak cerebrospinal fluid (CSF) pressure gradient (PG(p-p)) during the cardiac cycle, was obtained from the net transcranial blood and CSF flow measured with phase-contrast (PC) cine MRI. ICCI was determined in patients with I-NPH (N = 7), brain atrophy, or asymptomatic ventricular dilation (VD) (N = 6), and in healthy volunteers (control group; N = 11). The changes in ICCI indices were also analyzed after a CSF tap test (N = 2).Results: The ICCI in the I-NPH group was significantly lower than in the control and VD groups, whereas no difference was found between the control and VD groups. The ICVCp-p was also lower than in the control and VD groups. However, no significant difference was found in the PGp-p between groups. The ICCI increased after the tap test.Conclusion: Intracranial compliance analysis with MRI makes it possible to noninvasively obtain more detailed information of intracranial biomechanics in the I-NPH and to assist in the diagnosis of I-NPH.