Sesquiterpene lactone glycosides, eudesmanolides, and other constituents from Carpesium macrocephalum
Sesquiterpene lactone glycosides, eudesmanolides, and other constituents from Carpesium macrocephalum
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DOI：
10.1055/s-2002-32899
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发表时间：
2002-07-01
期刊：
影响因子：
2.7
通讯作者：
Jia, ZJ
中科院分区：
文献类型：
--
作者：
Yang, C;Shi, YP;Jia, ZJ
从大头壳种子中分离得到两个新倍半萜内酯糖苷和两个新月桂内酯以及12个已知化合物，分别鉴定为2α-O-β-D-葡萄糖基-5α，11αH-eudesma-4(15)-en-12，8-β-内酯(1)，2alpha-O-beta-D-glucopyranosyl-5alphaH-eudesma-4(15)，11(13)-dien-12，8beta-olide(2)，2alpha-acetoxy-5alpha-hydroxy-11alphaH-eudesma-4(15)-en.-12，8beta-olide(3)和2pha，5alpha-dihydroxy-11alphaH-eudesma-4(15)-en-12，8beta-olide(4)通过二维核磁共振技术(H-1-H-1COSY，H-1-H-1NOESY，HMQC，HMBC)和化学转化得到。化合物1、6、8、9和10具有中等的抗菌活性，化合物4对培养的人肝癌细胞SMMC-7721具有较强的细胞毒活性。
Two new sesquiterpene lactone glycosides and two new eudesmanolides, along with twelve known compounds were isolated from seeds of Carpesium macrocephalum, The structures of these new compounds were elucidated as 2alpha-O-beta-D-glucopyranosyl-5alpha, 11alphaH-eudesma-4(15)-en-12,8beta-olide (1), 2alpha-O-beta-D-glucopyranosyl-5alphaH-eudesma-4(15),11(13)-dien-12,8beta-olide (2), 2alpha-acetoxy-5alpha-hydroxy-11alphaH-eudesma-4(15)-en.-12,8beta-olide (3) and 2alpha,5alpha-dihydroxy-11alphaH-eudesma-4(15)-en-12,8beta-olide (4) by spectroscopic methods including 2D NMR techniques (H-1-H-1 COSY, H-1-H-1 NOESY, HMQC, HMBC) and chemical transformations. Compounds 1, 6, 8, 9 and 10 exhibited moderate antibacterial activity, while compound 4 showed appreciable cytotoxic activity against cultured SMMC-7721 (human hepatoma cell).