Human plasmacytoid dendritic cells sense lymphocytic choriomeningitis virus-infected cells in vitro.
Human plasmacytoid dendritic cells sense lymphocytic choriomeningitis virus-infected cells in vitro.
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人浆细胞样树突状细胞在体外感知淋巴细胞性脉络膜脑膜炎病毒感染的细胞。
DOI：
10.1128/jvi.01714-13
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发表时间：
2014
影响因子：
5.4
通讯作者：
Chisari,FV
中科院分区：
文献类型：
--
作者：
Wieland,SF;Takahashi,K;Boyd,B;Whitten-Bauer,C;Ngo,N;delaTorre,J-C;Chisari,FV
我们先前报道了丙型肝炎病毒（HCV）正链RNA从人Huh-7肝癌细胞外泌体转移到人浆细胞样树突状细胞（pDC）中，以Toll样受体7（TLR 7）依赖、病毒非依赖的方式触发pDC α/β干扰素（IFN-α/β）的产生。在这里，我们表明，人类pDC也激活TLR 7依赖性，病毒无关性，外泌体RNA转移机制的人类和小鼠肝癌和非肝癌细胞复制负链淋巴细胞性脉络丛脑膜炎病毒（LCMV）。
We previously reported that exosomal transfer of hepatitis C virus (HCV) positive-strand RNA from human Huh-7 hepatoma cells to human plasmacytoid dendritic cells (pDCs) triggers pDC alpha/beta interferon (IFN-α/β) production in a Toll-like receptor 7 (TLR7)-dependent, virus-independent manner. Here we show that human pDCs are also activated by a TLR7-dependent, virus-independent, exosomal RNA transfer mechanism by human and mouse hepatoma and nonhepatoma cells that replicate the negative-strand lymphocytic choriomeningitis virus (LCMV).