Suppression of chemical carcinogenesis by water-soluble organosulfur compounds
Suppression of chemical carcinogenesis by water-soluble organosulfur compounds
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DOI：
10.1093/jn/131.3.1049s
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发表时间：
2001-03-01
影响因子：
4.2
通讯作者：
Ogawa, M
中科院分区：
文献类型：
--
作者：
Fukushima, S;Takada, N;Ogawa, M
以二步法肝癌模型为基础，采用中期生物测定法，观察了S-甲基半胱氨酸等5种水溶性有机硫化合物及其类似物对雄性F344大鼠二乙基亚硝胺诱发肝癌的化学预防作用。此外，我们还研究了SMC和半胱氨酸对大鼠肝癌发生起始阶段的修饰作用。通过比较一个假定的肿瘤性病变--胎盘型谷胱甘肽S转移酶(GST-P)阳性肝细胞病灶的数量和面积，对致癌潜力进行评分。在Ito试验的推进阶段给予SMC和半胱氨酸可显著减少GST-P阳性灶的数目和面积。当在启动阶段给药时，这两种有机硫化合物也显著抑制焦点形成。在大鼠多器官致癌生物实验中，肝鸟氨酸脱羧酶活性和增殖细胞核抗原阳性的肝细胞比例显着减少了大鼠结肠内异常隐窝病灶的数量。这些结果支持SMC和半胱氨酸作为肝癌和结肠癌的化学预防药物。它们的摄入可能对癌症有重要作用。
The chemopreventive effects of five water-soluble organosulfur compounds, S-methylcysteine (SMC) and four analogs, were examined on the promotion stage of diethylnitrosamine hepatocarcinogenesis in male F344 rats, using the medium-term bioassay (Ito test), which is based on the two-step model of hepatocarcinogenesis. In addition, we investigated the modifying effects of SMC and cysteine on the initiation stage of rat hepatocarcinogenesis. Carcinogenic potential was scored by comparing the numbers and areas of a putative neoplastic lesion, glutathione S-transferase placental form (GST-P)-positive hepatocellular foci. SMC and cysteine significantly decreased the number and area of GST-P-positive foci when given in the promotion stage of the Ito test. When given during the initiation stage, these two organosulfur compounds also significantly inhibited focus formation. Liver ornithine decarboxylase activity after two thirds partial hepatectomy and the proportion of hepatocytes positive for proliferating cell nuclear antigen significantly decreased the number of aberrant crypt foci in the colon in a multiorgan carcinogenesis bioassay of rats. These results support SMC and cysteine as chemopreventive agents for hepatocarcinogenesis and colon carcinogenesis. Their intake may be of importance for cancer.