Visual experience regulates gene expression in the developing striate cortex.
Visual experience regulates gene expression in the developing striate cortex.
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视觉体验调节发育中的纹状皮层的基因表达。
DOI：
10.1073/pnas.86.12.4781
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发表时间：
1989
影响因子：
11.1
通讯作者：
Bear,MF
中科院分区：
文献类型：
--
作者：
Neve,RL;Bear,MF
我们研究了神经元生长相关蛋白GAP43、II型钙/钙调素依赖性蛋白激酶和谷氨酸脱羧酶基因在小猫视觉皮层正常发育期间和一段时间的视觉剥夺后的表达调控。我们发现这些基因的mRNA转录本显示出非常不同的正常发育模式，但在黑暗中饲养的动物的视觉皮层中都增加了。暴露于光下后，GAP43基因的转录本在12小时内下降到接近正常水平。
We have examined the regulation of expression of the genes for the neuronal growth-associated protein GAP43, the type II calcium/calmodulin-dependent protein kinase, and glutamic acid decarboxylase in the kitten visual cortex during normal postnatal development and after a period of visual deprivation. We find that the mRNA transcripts of these genes display very different patterns of normal development but are all increased in the visual cortex of animals reared in the dark. Upon exposure to light, the transcript of the GAP43 gene drops to near-normal levels within 12 hr.