Lactobacillus plantarum WSJ-06 alleviates neurobehavioral injury induced by lead in mice through the gut microbiota.
Lactobacillus plantarum WSJ-06 alleviates neurobehavioral injury induced by lead in mice through the gut microbiota.
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DOI：
10.1016/j.fct.2022.113308
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发表时间：
2022-07
期刊：
影响因子：
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通讯作者：
Yunting Li;Anfei Liu;Lixuan Chen;Yang Xiang;D. Huang;Wanwen Huang;Zhenhui Chen;H. Fan;
中科院分区：
文献类型：
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作者：
Yunting Li;Anfei Liu;Lixuan Chen;Yang Xiang;D. Huang;Wanwen Huang;Zhenhui Chen;H. Fan;
慢性铅暴露可导致认知功能障碍和行为障碍。然而，目前缓解铅中毒的治疗方法有许多副作用。以前的研究表明，益生菌可能有潜力改善铅暴露引起的神经毒性。本研究从肠道菌群和血清代谢产物的角度确定植物乳杆菌WSJ-06对慢性铅暴露引起的神经系统疾病的缓解作用。结果表明，植物乳杆菌WSJ-06治疗可减轻铅暴露引起的记忆功能障碍，并降低血清和海马中炎性细胞因子的水平。此外，植物乳杆菌WSJ-06部分恢复了铅诱导的肠道微生物群失调。它还增加了血清中一些有益代谢物的比例，如花生四烯酸，色氨酸羟化酶，血清素，维生素B12，海藻糖和犬尿氨酸，并减少了血清中的一些代谢物，如LPS 20：5和L-犬尿氨酸。相关性分析进一步表明铅引起的神经行为障碍与肠道菌群（[Eubacterium]_siraeum_group、Roseburia、Lactobacillus等）和血清代谢物（LPS 20：5、5-羟色胺、维生素B12等）有关。总之，植物乳杆菌WSJ-06通过调节血清中的肠道微生物群和代谢物来减轻铅暴露引起的神经炎症和记忆障碍。
Chronic lead exposure can result in cognitive dysfunction and behavioral disorders. However, the current treatments for alleviating lead poisoning have many side effects. Previous studies have suggested that probiotics may have the potential to ameliorate neurotoxicity caused by lead exposure. This study determines the alleviating effects of LactobacillusplantarumWSJ-06 on neurological disorders induced by chronic lead exposure from the perspective of the gut microbiota and serum metabolites. The results showed that treatment with Lactobacillus plantarum WSJ-06 alleviated memory dysfunction and reduced the levels of inflammatory cytokines in the serum and hippocampus induced by lead exposure. In addition,Lactobacillus plantarumWSJ-06 partially restored the lead-induced gut microbiota dysbiosis. It also increased the proportion of some beneficial metabolites in the serum, such as arachidonic acid, tryptophan hydroxylase, serotonin, vitamin B12, trehalose, and kynurenic acid, and decreased some metabolites in the serum, such as LPS 20:5 and L-kynurenine. A correlation analysis further indicated that lead-induced neurobehavioral disorders were related to intestinal microbiota (the[Eubacterium]_siraeum_group, Roseburia,Lactobacillus, etc) and serum metabolites (LPS 20:5, serotonin, vitamin B12, etc). In conclusion,Lactobacillus plantarumWSJ-06 alleviated neuroinflammation and memory impairment caused by lead exposure by modulating the gut microbiota and metabolites in the serum.