Genetic susceptibility to Alzheimer disease.
Genetic susceptibility to Alzheimer disease.
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DOI：
10.1016/s0168-9525(00)89161-1
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发表时间：
1995-12
期刊：
影响因子：
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通讯作者：
M. Pericak-Vance;J. Haines
中科院分区：
文献类型：
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作者：
M. Pericak-Vance;J. Haines
阿尔茨海默病（Alzheimer disease，AD）是老年痴呆的主要病因。不到十年前，人们质疑基因是否与罕见的早发性AD有关。从那时起，使用各种遗传流行病学和分子生物学技术，已经确定了四个基因座在AD的遗传易感性中起作用，AD作为遗传技术在定义复杂疾病的病因学方面的力量的原型。
Alzheimer disease (AD) is the leading cause of dementia in the elderly. Less than a decade ago, it was questioned as to whether or not genes were even involved in anything but rare early onset AD. Since that time, using a variety of genetic epidemiological and molecular biological techniques, four loci have been identified that play a role in the genetic susceptibility of AD, AD presents as a prototype of the power of genetic techniques in defining the etiology of a complex disease.