Just say 'know': how do cannabinoid concentrations influence users' estimates of cannabis potency and the amount they roll in joints?
Just say 'know': how do cannabinoid concentrations influence users' estimates of cannabis potency and the amount they roll in joints?
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DOI：
10.1111/add.12634
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发表时间：
2014-10-01
期刊：
影响因子：
6
通讯作者：
Curran, H. Valerie
中科院分区：
文献类型：
--
作者：
Freeman, Tom P.;Morgan, Celia J. A.;Curran, H. Valerie
目的（1）确定个人自己的大麻中δ-9-四氢大麻酚（THC）和大麻二酚（CBD）的测量浓度是否预测了他们对药物效力和实际滴定的估计;以及（2）确定这些影响是否受到使用频率和大麻类型的影响。设计横截面，自然主义。设置参与者自己的家。参与者在英国共有247名大麻使用者：152名娱乐“（1-24天/月）和95名每日”（25天/月）。方法参与者在研究人员面前吸食大麻之前，对自己的大麻的效力（1-10）和类型（树脂，草药，臭鼬）进行评级。记录了他们关节中使用的大麻量（g），并分析了THC和CBD浓度（%）的额外样本。结果四氢大麻酚浓度与大麻使用量呈负相关[非标准化回归系数：B=-0.009，95%置信区间（CI）=-0.017，-0.002]。通过增加THC来预测效力估计值（B=0.055，95% CI=0.020，0.090）和CBD降低（B=-0.160，95% CI=-0.284，-0.062），且这两种关联均由大麻类型介导（THC：B=0.018，95% CI=0.006，0.037; CBD：B=-0.105，95% CI=-0.198，-0.028）。随着使用频率的增加，效力估计值更能反映THC（B=0.004，95% CI=0.001，0.007），每日效力估计值（部分r=0.381）是娱乐性使用者（r=0.052）的7.3倍。结论：当在自然环境中使用自己的大麻时，人们根据δ-9-四氢大麻酚（THC）而不是大麻二酚（CBD）的浓度来滴定他们在关节中滚动的量。因此，长期吸毒者对大麻的效力了解不多。
Aims (1) To determine whether measured concentrations of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in individuals' own cannabis predict their estimates of drug potency and actual titration; and (2) to ascertain if these effects are influenced by frequency of use and cannabis type. Design Cross-sectional, naturalistic. Setting Participants' own homes. Participants A total of 247 cannabis users in the United Kingdom: 152 recreational' (1-24 days/month) and 95 daily' (25 days/month). Methods Participants rated their own cannabis for its potency (1-10) and type (resin', herbal', skunk') before smoking it in front of the researcher. The amount of cannabis (g) used in their joints was recorded and an additional sample was analysed for THC and CBD concentrations (%). Findings THC concentrations were related negatively to the amount of cannabis used [unstandardized regression coefficient: b=-0.009, 95% confidence interval (CI)=-0.017, -0.002]. Potency estimates were predicted by increasing THC (b=0.055, 95% CI=0.020, 0.090) and decreasing CBD (b=-0.160, 95% CI=-0.284, -0.062), and both of these associations were mediated by cannabis type (THC: b=0.018, 95% CI=0.006, 0.037; CBD: b=-0.105, 95% CI=-0.198, -0.028). Potency estimates were more reflective of THC as frequency of use increased (b=0.004, 95% CI=0.001, 0.007) and were 7.3 times more so in daily (partial r=0.381) than recreational users (r=0.052). Conclusions When using their own cannabis in a naturalistic setting, people titrate the amount they roll in joints according to concentrations of delta-9-tetrahydrocannabinol (THC) but not cannabidiol (CBD). Recreational users thus show poor understanding of cannabis potency.