Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia.
Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia.
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清髓性骨髓移植对镰状细胞性贫血儿童生长的影响：造血细胞移植治疗镰状细胞性贫血的多中心研究结果。
DOI：
10.1111/j.1365-2141.2006.06486.x
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发表时间：
2007
影响因子：
6.5
通讯作者：
Redding-Lall
中科院分区：
文献类型：
--
作者：
Eggleston,B;Patience,M;Edwards,S;Adamkiewicz,T;Buchanan,GR;Davies,SC;Dickerhoff,R;Donfield,S;Feig,SA;Giller,RH;Haight,A;Horan,J;Hsu,LL;Kamani,N;Lane,P;Levine,JE;Margolis,D;Moore,TB;Ohene-Frempong,K;Redding-Lall
虽然造血细胞移植（HCT）可以治愈镰状细胞贫血（SCA），但对其短期和长期毒性的担忧限制了其应用。潜在的毒性是对生长的不利影响。为了确定HCT生长效应，我们将53名接受移植后患有SCA的儿童和青少年的连续身高和体重测量与历史对照进行了比较。纵向数据采用层次线性模型进行分析。一般来说，幼儿SCA的HCT未损害生长；然而，如果在青春期生长高峰附近或期间进行HCT，可能会出现生长减少。
Although haematopoietic cell transplantation (HCT) is curative for sickle cell anaemia (SCA), concerns about its short‐ and long‐term toxicities limit its application. A potential toxicity is an adverse effect on growth. To identify an HCT growth effect, serial height and weight measurements from 53 children and adolescents with SCA after receiving a transplant were compared to historical controls. Hierarchical Linear Models for longitudinal data were used for analysis. In general growth was not impaired by HCT for SCA in young children; however, diminished growth may occur if HCT is carried out near or during the adolescent growth spurt.