Organizing moving groups during morphogenesis
Organizing moving groups during morphogenesis
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DOI：
10.1016/j.ceb.2005.12.001
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发表时间：
2006-02-01
影响因子：
7.5
通讯作者：
Gilmour, D
中科院分区：
文献类型：
--
作者：
Lecaudey, V;Gilmour, D
细胞的定向迁移驱动许多复杂器官系统的形成。虽然在这种形态发生背景下，细胞表现出强烈的偏好迁移在有组织的，有凝聚力的群体，很少有人知道的机制，协调他们的运动。最近对几种模型系统的研究已经开始解剖这些迁移组织在体内的组织，并已表明，细胞引导介导的化学和机械线索的组合。
The directed migration of cells drives the formation of many complex organ systems. Although in this morphogenetic context cells display a strong preference for migrating in organized, cohesive groups, little is known about the mechanisms that coordinate their movements. Recent studies on several model systems have begun to dissect the organization of these migrating tissues in vivo and have shown that cell guidance is mediated by a combination of chemical and mechanical cues.