Impact of Supplementation with Curcuminoids on Systemic Inflammation in Patients with Knee Osteoarthritis: Findings from a Randomized Double-Blind Placebo-Controlled Trial
Impact of Supplementation with Curcuminoids on Systemic Inflammation in Patients with Knee Osteoarthritis: Findings from a Randomized Double-Blind Placebo-Controlled Trial
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DOI：
10.1055/s-0034-1384536
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发表时间：
2015-10-01
期刊：
影响因子：
2.2
通讯作者：
Sahebkar, A.
中科院分区：
文献类型：
--
作者：
Rahimnia, A. -R.;Panahi, Y.;Sahebkar, A.
目的：骨关节炎（OA）是一种与炎症相关的退行性关节疾病。本研究旨在确定临床症状因补充姜黄素而改善的OA患者血清炎症生物标志物水平的变化。方法：本研究是一项随机双盲安慰剂对照平行组临床试验，其中40例轻度至中度膝关节OA患者随机分配接受纯姜黄素（1500mg/天，分3次剂量，n=19）或匹配安慰剂（n=21），为期6周。为了提高姜黄素的生物利用度，在治疗方案中加入胡椒碱（15mg/天）。在基线和试验结束时测定血清白细胞介素4 （IL-4）和6 （IL-6）、肿瘤坏死因子- (TNF-)、转化生长因子- (TGF-)和高敏c反应蛋白（hs-CRP）水平以及红细胞沉降率（ESR）。结果：姜黄素组血清IL-4 （p=0.001）、IL-6 （p=0.006）和hs-CRP （p=0.004）浓度显著降低，而血清TNF-、TGF-水平和平均ESR水平在试验结束时保持不变（p < 0.05）。安慰剂组血清IL-4 （p=0.001）、IL-6 （p=0.003）、TNF- (p=0.003)、TGF- (p=0.005)浓度显著降低，但hs-CRP和ESR平均值无统计学变化（p < 0.05）。比较评估的炎症生物标志物的变化幅度，各组之间没有显着差异（p>0.05）。结论：姜黄素治疗的OA患者临床症状的显著改善不能归因于这些植物化学物质的全身抗炎作用。
Objective: Osteoarthritis (OA) is a degenerative joint disease associated with inflammation. The present study aimed to determine changes in serum levels of inflammatory biomarkers in OA patients whose clinical symptoms were improved as a result of supplementation with curcuminoids.Methods: This study was a randomized double-blind placebo-control parallel-group clinical trial in which 40 subjects with mild-to-moderate degree knee OA were randomly allocated to receive either pure curcuminoids (1500mg/day in 3 divided doses; n=19) or matched placebo (n=21) for 6 weeks. In order to enhance the bioavailability of curcuminoids, piperine (15mg/day) was added to the treatment regimen. Serum levels of interleukins 4 (IL-4) and 6 (IL-6), tumor necrosis factor- (TNF-), transforming growth factor- (TGF-) and high-sensitivity C-reactive protein (hs-CRP), together with erythrocyte sedimentation rate (ESR) were determined at baseline as well as at the end of trial.Results: Serum concentrations of IL-4 (p=0.001), IL-6 (p=0.006) and hs-CRP (p=0.004) were significantly reduced in the curcuminoid group whilst serum levels of TNF- and TGF- and mean ESR remained unaltered by the end of trial (p>0.05). In the placebo group, serum concentrations of IL-4 (p=0.001), IL-6 (p=0.003), TNF- (p=0.003) and TGF- (p=0.005) were significantly reduced but mean hs-CRP and ESR values remained statistically unchanged (p>0.05). Comparison of the magnitude of changes in the evaluated inflammatory biomarkers did not indicate any significant difference between the study groups (p>0.05).Conclusion: Significant improvement in clinical symptoms of OA in curcuminoid-treated subjects cannot be attributed to the systemic anti-inflammatory effects of these phytochemicals.