Meta-analyses of Theory Use in Medication Adherence Intervention Research
Meta-analyses of Theory Use in Medication Adherence Intervention Research
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DOI：
10.5993/ajhb.40.2.1
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发表时间：
2016-03-01
影响因子：
2.3
通讯作者：
Chan, Keith C.
中科院分区：
文献类型：
--
作者：
Conn, Vicki S.;Enriquez, Maithe;Chan, Keith C.
目的：本系统性综述应用荟萃分析程序整合了主要研究，这些研究检查了与理论或模型相关的药物依从性干预措施。研究方法：采用广泛的文献检索策略来定位试验，这些试验通过电子事件监测、药房续药、药丸计数和自我报告来测量药物依从性行为结局。随机效应模型分析用于计算药物依从性结局的标准化平均差异效应量。结果：从19，348名参与者的146项比较中提取了可编码数据。最常见的理论和模型是社会认知理论和动机访谈。所有干预措施比较治疗组和对照组参与者的总体加权效应量为0.294。基于单一理论的干预措施的效应量为0.323，多理论干预措施的效应量为0.214。个别理论和模型的效应量范围为0.041至0.447。最大的效应量是基于健康信念模型（0.477）和成人学习理论（0.443）的干预措施。基于PRECEDE（0.041）和自我调节（0.118）的干预措施的效应量最小。结论：这些研究结果表明，理论和模型相关的干预措施对药物依从性结果有显着但适度的影响。
Objective: This systematic review applied meta-analytic procedures to integrate primary research that examined theory-or model-linked medication adherence interventions. Methods: Extensive literature searching strategies were used to locate trials testing interventions with medication adherence behavior outcomes measured by electronic event monitoring, pharmacy refills, pill counts, and self-reports. Random-effects model analysis was used to calculate standardized mean difference effect sizes for medication adherence outcomes. Results: Codable data were extracted from 146 comparisons with 19,348 participants. The most common theories and models were social cognitive theory and motivational interviewing. The overall weighted effect size for all interventions comparing treatment and control participants was 0.294. The effect size for interventions based on single-theories was 0.323 and for multiple-theory interventions was 0.214. Effect sizes for individual theories and models ranged from 0.041 to 0.447. The largest effect sizes were for interventions based on the health belief model (0.477) and adult learning theory (0.443). The smallest effect sizes were for interventions based on PRECEDE (0.041) and self-regulation (0.118). Conclusion: These findings suggest that theory-and model-linked interventions have a significant but modest effect on medication adherence outcomes.