Effect of sodium-restricted diet and posture on norepinephrine kinetics in humans.
Effect of sodium-restricted diet and posture on norepinephrine kinetics in humans.
复制标题
限制钠饮食和姿势对人类去甲肾上腺素动力学的影响。
DOI：
10.1152/ajpendo.1988.254.2.e222
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Halter,JB
中科院分区：
文献类型：
--
作者：
Linares,OA;Zech,LA;Jacquez,JA;Rosen,SG;Sanfield,JA;Morrow,LA;Supiano,MA;Halter,JB
我们用隔室分析的方法分析了去甲肾上腺素(NE)在人体内的分布和代谢动力学，并确定了人体限钠时血浆去甲肾上腺素浓度(PNE)的升高是否与交感神经系统(SNS)的激活有关。在正常钠(NS)饮食和每日限钠(SR)饮食7天后，测定了青年受试者在仰卧位和站立60min时[~3H]-NE的输注和输注后的衰变。SR饮食组的平均仰卧位PNE高于NS饮食组(154+/-9pg/ml比185+/-12pg/ml，P=0.02，n=10)。在生理盐水和SR饲料中，直立性PNE均增加(分别为163+/-4vs.359+/-38pg/ml和182+/-8vs.401+/-26pg/ml，多变量单向方差分析，P<0.001，α=0.0 5)。无论是SR饮食还是直立姿势，PNE的增加都伴随着NE代谢清除率(MCR1)的下降。在SR饮食期间，这是由于NE的分布量下降(6.1%+/-0.4vs.5.0+/-0.4L，P=0.003，n=10)。与直立姿势增加去甲肾上腺素(NE)释放到血管外室(NE2)的效果相反，SR饮食期间NE2没有变化(1.63+/-0.09比1.62+/-0.1微克·min-1.m-2，P=0.97，n=10)。因此，在人类SR饮食过程中，PNE的增加可以用NE分布量的下降，导致MCR1的减少来解释。
We used compartmental analysis to analyze the kinetics of distribution and metabolism of norepinephrine (NE) and to determine whether the increase in plasma norepinephrine concentration (PNE) during sodium restriction in humans is due to sympathetic nervous system (SNS) activation. [3H]-NE infusion and postinfusion decay were measured in young subjects in the supine position and during 60 min of standing during normal sodium (NS) diet and after 7 days of 10 meq/day sodium-restricted (SR) diet. The mean supine PNE was greater during SR diet compared with NS diet (154 +/- 9 vs. 185 +/- 12 pg/ml, P = 0.02, n = 10). During both NS and SR diets, upright PNE increased (163 +/- 4 vs. 359 +/- 38 pg/ml and 182 +/- 8 vs. 401 +/- 26 pg/ml, respectively, multivariate one-way analysis of variance, P less than 0.001, alpha = 0.05). The increases of PNE with both SR diet and upright posture were accompanied by a fall in NE metabolic clearance rate (MCR1). During SR diet this was due to a fall in the volume of distribution of NE (6.1 +/- 0.4 vs. 5.0 +/- 0.4 liters, P = 0.003, n = 10). In contrast to the effect of upright posture to increase NE release into the extra-vascular compartment (NE2), during SR diet there was no change in NE2 (1.63 +/- 0.09 vs. 1.62 +/- 0.1 micrograms.min-1.m-2, P = 0.97, n = 10). Thus the increase in PNE during SR diet in humans can be explained by a fall in the volume of distribution of NE, resulting in a decrease in MCR1.(ABSTRACT TRUNCATED AT 250 WORDS)