Influence of maternal smoking on neonatal aortic intima-media thickness, serum IGF-I and IGFBP-3 levels
Influence of maternal smoking on neonatal aortic intima-media thickness, serum IGF-I and IGFBP-3 levels
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DOI：
10.1007/s00431-006-0376-9
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发表时间：
2007-10-01
影响因子：
3.6
通讯作者：
Koklu, Selmin
中科院分区：
文献类型：
--
作者：
Gunes, Tamer;Koklu, Esad;Koklu, Selmin
流行病学研究报告了一系列心血管危险因素之间的关联，如吸烟和内膜中层厚度（IMT）。一些报告指出，母亲吸烟会导致胎儿内分泌状况紊乱。胰岛素样生长因子I（IGF-I）可以局部或全身方式改变动脉粥样硬化过程，这有几种潜在的机制。本研究的目的是探讨母亲吸烟对新生儿主动脉内膜中层厚度（aIMT）、血清胰岛素样生长因子-I（IGF-I）和胰岛素样生长因子结合蛋白-3（IGFBP-3）水平的影响。测量了28名母亲在怀孕期间吸烟的新生儿和28名对照新生儿的主动脉内膜中层厚度。母亲吸烟的新生儿的平均和体重校正aIMT（分别为0.455 +/- 0.009 mm和0.151 +/- 0.005 mm/kg）显著高于对照组（分别为0.403 +/- 0.029 mm和0.118 +/- 0.014 mm/kg）。母亲吸烟的新生儿体重低于对照组。在母亲吸烟的婴儿中观察到的血清IGF-I和IGFBP-3的降低不显著。平均aIMT与出生体重和IGF-I水平呈负相关。总之，母亲吸烟的新生儿aIMT显著增加。它可能在成人动脉粥样硬化的发病机制中起作用。
Epidemiological studies have reported associations between a range of cardiovascular risk factors such as smoking and intima-media thickness (IMT). Some reports indicate that the maternal tobacco smoking causes disturbances of the endocrine status of the foetus. There are several potential mechanisms by which insulin-like growth factor I (IGF-I) could modify atherosclerotic processes either locally or in a systemic manner. The aim of this study was to investigate the influence of maternal smoking on neonatal aortic IMT (aIMT), serum IGF-I and IGF-binding protein-3 (IGFBP-3) levels. Aortic intima-media thickness was measured in 28 neonates whose mothers smoked during the pregnancy and 28 control neonates. Mean and weight-adjusted aIMT were significantly greater in the neonates whose mothers smoked (0.455 +/- 0.009 mm and 0.151 +/- 0.005 mm/kg, respectively) than in controls (0.403 +/- 0.029 mm and 0.118 +/- 0.014 mm/kg, respectively). Birth-weight of newborns whose mothers smoked was less than that of the controls. The decreases in serum IGF-I and IGFBP-3 observed in the infants whose mothers smoked were non-significant. Mean aIMT was negatively associated with birth-weight and IGF-I level. In conclusion, neonates whose mothers smoked have significantly increased aIMT. It might play a role in the pathogenesis of atherosclerosis in adult life.