Impact of two rounds of praziquantel mass drug administration on Schistosoma mansoni infection prevalence and intensity: a comparison between community wide treatment and school based treatment in western Kenya.
Impact of two rounds of praziquantel mass drug administration on Schistosoma mansoni infection prevalence and intensity: a comparison between community wide treatment and school based treatment in western Kenya.
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DOI：
10.1016/j.ijpara.2016.01.006
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发表时间：
2016-06
影响因子：
4
通讯作者：
Montgomery SP
中科院分区：
文献类型：
--
作者：
Onkanga IO;Mwinzi PN;Muchiri G;Andiego K;Omedo M;Karanja DM;Wiegand RE;Secor WE;Montgomery SP
比较了血吸虫病的大量给药途径。该研究报告了一项为期5年的研究的中期分析结果。以学校和社区为基础的分布也产生了类似的患病率下降。校本分布对感染强度的影响较大。这项研究比较了在肯尼亚西部流行率大于或等于25%的村庄中，社区治疗和基于学校的治疗方法在控制曼氏血吸虫感染中的有效性。采用Kato-Katz技术对一年级学生、9-12岁儿童和成人（20-55岁）的粪便样本进行曼氏沙门氏菌卵分析。两轮治疗后，两种治疗方法的曼氏链球菌患病率和强度水平均显著下降。两种方法之间的患病率比较在治疗后没有显示任何显著差异。然而，社区治疗组的9-12岁在校学生感染强度明显高于学校治疗组。然而，无论采用何种治疗方法，学龄儿童的曼氏链球菌感染流行率和强度水平均显著降低。
Comparison of mass drug administration approaches for schistosomiasis was performed. The study presents results of a mid-term analysis of a 5 year study. School-based and community-wide distribution yielded a similar prevalence decrease. School-based distribution had a greater impact on intensity of infection. This study compared the effectiveness of the community-wide treatment and school-based treatment approaches in the control of Schistosoma mansoni infections in villages with ⩾25% prevalence in western Kenya. Stool samples from first year students, 9–12 year olds and adults (20–55 years) were analyzed by the Kato–Katz technique for S. mansoni eggs. After two rounds of treatment, S. mansoni prevalence and intensity levels significantly declined in both treatment approaches. Prevalence comparisons between the two approaches did not show any significant differences following treatment. However, infection intensity levels in the 9–12 year old school-attending pupils were significantly higher in the community-wide treatment arm than in the school-based treatment arm. Nevertheless, significant reductions in S. mansoni infection prevalence and intensity levels were achieved among school-age children regardless of the treatment approach used.