PHYSIOLOGIC REGULATION OF THE SERUM CONCENTRATION OF 1,25-DIHYDROXYVITAMIN-D BY PHOSPHORUS IN NORMAL MEN
PHYSIOLOGIC REGULATION OF THE SERUM CONCENTRATION OF 1,25-DIHYDROXYVITAMIN-D BY PHOSPHORUS IN NORMAL MEN
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DOI：
10.1172/jci114043
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发表时间：
1989-05-01
影响因子：
15.9
通讯作者：
MORRIS, RC
中科院分区：
文献类型：
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作者：
PORTALE, AA;HALLORAN, BP;MORRIS, RC
我们问了这个问题：在正常人中，正常饮食摄入或正常血清磷浓度是1，25（OH）2D血清浓度的决定因素吗？在严格控制的正常代谢条件下，7名正常男性的膳食磷从2，300 mg/d降至625 mg/d，每次摄入8-9 d，我们每天测量血清1，25（OH）2D浓度，并在限制前后的24小时内每小时测量磷浓度。降低膳食磷诱导：（a）血清1，25（OH）2D水平增加58%;（B）下午测量的血清磷水平降低35%;（c）24小时平均血清磷水平降低12%;但（d）早晨空腹磷水平没有降低。血清1，25（OH）2D浓度与24 h平均磷浓度呈显著负相关（r =-0.77，P < 0.001）。当这些数据与我们先前的研究（其中膳食磷在极端范围内变化）相结合时，血清1，25（OH）2D水平与24小时平均血清磷水平之间的相关性甚至更强（r =-0.90，P < 0.001）。总体而言，结果表明，在正常男性中，膳食磷甚至更强（r =-0.90，P < 0.001）。在聚集体中，结果表明，在正常男性中，在整个正常范围内和超出范围的膳食磷，可以精细地调节肾脏生产和血清中的1，25（OH）2D浓度，并提供证据表明，这种调节是通过精细调节血清中磷浓度介导的。
We asked this question: in normal humans, is either a normal dietary intake or normal serum concentration of phosphorus a determinant of the serum concentration of 1,25(OH)2D? In seven normal men whose dietary phosphorus was decreased from 2,300 to 625 mg/d, each intake for 8-9 d, under strictly controlled, normal metabolic conditions, we measured serum concentrations of 1,25(OH)2D daily, and concentrations of phosphorus hourly throughout a 24-h period, before and after restriction. Decreasing dietary phosphorus induced: (a) a 58% increase in serum levels of 1,25(OH)2D; (b) a 35% decrease in serum levels of phosphorus measured in the afternoon; (c) a 12% decrease in the 24-h mean serum level of phosphorus; but (d) no decrease in morning fasting levels of phosphorus. Serum concentrations of 1,25(OH)2D varied inversely and significantly with 24-h mean concentrations of phosphorus (r = -0.77, P < 0.001). When these data are combined with those of our prior study in which dietary phosphorus was varied over an extreme range, the relationship between serum levels of 1,25(OH)2D and 24-h mean serum levels of phosphorus is even stronger (r = -0.90, P < 0.001). In the aggregate, the results demonstrate that in normal men, dietary phosphorus is even stronger (r = -0.90, P < 0.001). In the aggregates, the results demonstrate that in normal men, dietary phosphorus throughout a normal range and beyond, can finely regulate the renal production and serum concentration of 1,25(OH)2D, and provide evidence that this regulation is mediated by fine modulation of the the serum concentration of phosphorus.