Spontaneously hypertensive rats exhibit reduced hypothalamic noradrenergic input after NaCl loading.
Spontaneously hypertensive rats exhibit reduced hypothalamic noradrenergic input after NaCl loading.
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自发性高血压大鼠在 NaCl 负荷后表现出下丘脑去甲肾上腺素能输入减少。
DOI：
10.1161/01.hyp.10.3.313
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Oparil,S
中科院分区：
文献类型：
--
作者：
Wyss,JM;Chen,YF;Jin,H;Gist,R;Oparil,S
自发性高血压大鼠（SHR）的冈本株表现出显着加剧高血压的严重程度时，饲料中高氯化钠。为了检验下丘脑和脑干的单胺能神经支配异常导致NaCl诱导的高血压恶化的假设，在SHR中测定了被认为参与高血压发病机制的特定下丘脑和脑干区域的单胺和单胺代谢物含量，SHR从8周龄开始喂食含有8%或1%NaCl的饮食2或6周。SHR维持在8%NaCl饮食2周显示显着降低去甲肾上腺素在前和后下丘脑区域，但不是在其他脑干或下丘脑区域，与动物消耗1%NaCl相比。此外，商店的主要终端去甲肾上腺素代谢产物3-甲氧基-4-羟基苯乙二醇减少在SHR的前下丘脑区域喂食8%NaCl饮食2周。6周后的饮食，SHR喂养8%NaCl显示小，但统计学上不显着减少前下丘脑区域的去甲肾上腺素商店相比，SHR喂养基础饮食，而WKY喂养8%NaCl有显着升高前下丘脑区域的去甲肾上腺素商店相比，WKY喂养基础饮食。存在显著的组X饮食相互作用（p小于0.05）。6周后，8%NaCl饮食，SHR（但不是WKY）显示出显着减少去甲肾上腺素含量的后下丘脑区域。无NaCl诱导的差异，去甲肾上腺素商店被发现在脑桥或髓质的任何应变。（250字处删节）
Spontaneously hypertensive rats (SHR) of the Okamoto strain exhibit a significant exacerbation in severity of hypertension when fed diets high in NaCl. To examine the hypothesis that abnormalities in the monoaminergic innervation of the hypothalamus and brainstem contribute to the NaCl-induced exacerbation of hypertension, the monoamine and monoamine metabolite contents of specific hypothalamic and brainstem regions thought to be involved in the pathogenesis of hypertension were determined in SHR fed a diet containing 8% or 1% NaCl for either 2 or 6 weeks beginning at age 8 weeks. SHR maintained on the 8% NaCl diet for 2 weeks displayed significant decreases in norepinephrine in both the anterior and posterior hypothalamic regions but not in other brainstem or hypothalamic regions, as compared with animals consuming 1% NaCl. In addition, stores of the principal terminal norepinephrine metabolite 3-methoxy-4-hydroxyphenylglycol were reduced in the anterior hypothalamic region of SHR fed an 8% NaCl diet for 2 weeks. After 6 weeks on the diets, SHR fed 8% NaCl showed small but statistically nonsignificant reductions in norepinephrine stores of the anterior hypothalamic region as compared with SHR fed a basal diet, while WKY fed 8% NaCl had significantly elevated norepinephrine stores in the anterior hypothalamic region as compared with WKY fed a basal diet. There was a significant group X diet interaction (p less than 0.05). After 6 weeks on the 8% NaCl diet, SHR (but not WKY) displayed a significant reduction in norepinephrine content of the posterior hypothalamic region. No NaCl-induced differences in norepinephrine stores were found in the pons or medulla of either strain.(ABSTRACT TRUNCATED AT 250 WORDS)