HLA class II associations in juvenile Graves' disease: indication of a strong protective role of the DRB1*0701,DQA1*0201 haplotype
HLA class II associations in juvenile Graves' disease: indication of a strong protective role of the DRB1*0701,DQA1*0201 haplotype
复制标题
DOI：
10.1111/j.1399-0039.1997.tb02922.x
复制
发表时间：
1997-12-01
期刊：
影响因子：
--
通讯作者：
Svejgaard, A
中科院分区：
文献类型：
--
作者：
Lavard, L;Madsen, HO;Svejgaard, A
既往研究表明HLA-DRB 1 *0301和DQA 1 *0501与Graves病易感性相关。对90名丹麦早期发病的Graves病患者和102-192名对照者进行了HLA-DR和-DQ分析，以调查在青少年形式的Graves病中是否存在相同的关联。DRB 1 *0301和DQA 1 *0501在相对风险为8.0和4.6的患者中均显著增加，高于成年人。分层显示DRB 1 *0301比DQA 1 *0501更强相关。令人惊讶的是，DRB 1 *0701，DQA 1 *0201单倍型在该组患者中完全不存在，表明该单倍型在青少年Graves病中具有强保护作用。
Previous studies have shown that HLA-DRB1*0301 and DQA1*0501 are associated with susceptibility to Graves' disease. Ninety Danish patients with early onset of Graves' disease and 102-192 controls were analyzed for HLA-DR and -DQ to investigate if the same associations exist in the juvenile form of Graves' disease. Both DRB1*0301 and DQA1*0501 were highly significantly increased in the patients with relative risks of 8.0 and 4.6, which are higher than those seen in adults. Stratification showed that DRB1*0301 is more strongly associated than DQA1*0501. Surprisingly, the DRB1*0701,DQA1*0201 haplotype was completely absent from this group of patients, indicating a strong protective role of this haplotype in juvenile Graves' disease.