UniCarbKB: building a knowledge platform for glycoproteomics.
UniCarbKB: building a knowledge platform for glycoproteomics.
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DOI：
10.1093/nar/gkt1128
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发表时间：
2014-01
影响因子：
14.9
通讯作者：
Packer NH
中科院分区：
文献类型：
--
作者：
Campbell MP;Peterson R;Mariethoz J;Gasteiger E;Akune Y;Aoki-Kinoshita KF;Lisacek F;Packer NH
UniCarb知识库（UniCarbKB; http://unicarbkb.org）为公众提供了对糖蛋白聚糖结构信息的不断增长的精选数据库的访问。UniCarbKB是一项国际努力，旨在通过整合结构，实验和功能糖科学信息，进一步了解糖基化和糖介导过程中涉及的结构，途径和网络。该计划建立在聚糖结构数据库GlycoSuiteDB的成功基础上，以及EUROCarbDB引入的信息标准，为支持糖组学和糖蛋白质组学研究提供高质量和更新的资源。UniCarbKB提供有关聚糖结构的全面信息，以及已发表的糖蛋白信息，包括全局和位点特异性连接信息。第一次发布超过890篇参考文献，3740个聚糖结构条目和400个糖蛋白。此外，598个蛋白质糖基化位点已经用来自文献的实验证实的聚糖结构注释。其中包括35种糖蛋白，502种结构和60种以前未包含在GlycoSuiteDB中的出版物。本文提供了GlycoSuiteDB（在以前的NAR数据库问题中有介绍，自2009年以来由ExPASy托管）到UniCarbKB的转换及其与UniProtKB和GlycoMod的集成的更新。在这里，我们介绍了一个重构的数据库，由大量新的策划数据集合和直观的用户界面，提高数据库搜索的支持。
The UniCarb KnowledgeBase (UniCarbKB; http://unicarbkb.org) offers public access to a growing, curated database of information on the glycan structures of glycoproteins. UniCarbKB is an international effort that aims to further our understanding of structures, pathways and networks involved in glycosylation and glyco-mediated processes by integrating structural, experimental and functional glycoscience information. This initiative builds upon the success of the glycan structure database GlycoSuiteDB, together with the informatic standards introduced by EUROCarbDB, to provide a high-quality and updated resource to support glycomics and glycoproteomics research. UniCarbKB provides comprehensive information concerning glycan structures, and published glycoprotein information including global and site-specific attachment information. For the first release over 890 references, 3740 glycan structure entries and 400 glycoproteins have been curated. Further, 598 protein glycosylation sites have been annotated with experimentally confirmed glycan structures from the literature. Among these are 35 glycoproteins, 502 structures and 60 publications previously not included in GlycoSuiteDB. This article provides an update on the transformation of GlycoSuiteDB (featured in previous NAR Database issues and hosted by ExPASy since 2009) to UniCarbKB and its integration with UniProtKB and GlycoMod. Here, we introduce a refactored database, supported by substantial new curated data collections and intuitive user-interfaces that improve database searching.
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影响因子：
4.3
作者：
Thaysen-Andersen, Morten;Packer, Nicolle H.
通讯作者：
Packer, Nicolle H.
影响因子：
--
作者：
Ceroni A;Dell A;Haslam SM
通讯作者：
Haslam SM
影响因子：
14.9
作者：
Cooper, CA;Joshi, HJ;Packer, NH
通讯作者：
Packer, NH
影响因子：
3.1
作者：
Herget, S.;Ranzinger, R.;Von der Lieth, C. -W.
通讯作者：
Von der Lieth, C. -W.
影响因子：
3.4
作者：
Campbell, Matthew P.;Hayes, Catherine A.;Packer, Nicolle H.
通讯作者：
Packer, Nicolle H.