A National Study of Outcomes among HIV-Infected Kidney Transplant Recipients
A National Study of Outcomes among HIV-Infected Kidney Transplant Recipients
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DOI：
10.1681/asn.2014070726
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发表时间：
2015-09-01
影响因子：
13.6
通讯作者：
Segev, Dorry L.
中科院分区：
文献类型：
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作者：
Locke, Jayme E.;Mehta, Shikha;Segev, Dorry L.
肾移植是治疗艾滋病毒和终末期肾病患者的一种可行方法，但缺乏关于长期结果的数据，以及与适当匹配的艾滋病毒阴性患者的比较。我们分析了来自移植受者科学登记处(SRTR；2002-2011)的数据：510名携带艾滋病毒的成人肾移植受者(平均随访3.8年)与HIV阴性对照组的比例为1：10。与HIV阴性对照相比，感染HIV的受者移植后5年(75.3%比69.2%)和10年(54.4%比49.8%)存活率(GS)显著降低(风险比[HR]，1.37；95%可信区间[95%CI]，1.15至1.64；P
Kidney transplantation is a viable treatment for select patients with HIV and ESRD, but data are lacking regarding long-term outcomes and comparisons with appropriately matched HIV-negative patients. We analyzed data from the Scientific Registry of Transplant Recipients (SRTR; 2002-2011): 510 adult kidney transplant recipients with HIV (median follow-up, 3.8 years) matched 1:10 to HIV-negative controls. Compared with HIV-negative controls, HIV-infected recipients had significantly lower 5-year (75.3% versus 69.2%) and 10-year (54.4% versus 49.8%) post-transplant graft survival (GS) (hazard ratio [HR], 1.37; 95% confidence interval [95% CI], 1.15 to 1.64; P