In Depth Study on Solution-State Structure of Poly(lactic acid) by Vibrational Circular Dichroism
In Depth Study on Solution-State Structure of Poly(lactic acid) by Vibrational Circular Dichroism
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DOI：
10.1021/ma501020s
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发表时间：
2014-08-12
期刊：
影响因子：
5.5
通讯作者：
Monde, Kenji
中科院分区：
文献类型：
--
作者：
Hongen, Takahiro;Taniguchi, Tohru;Monde, Kenji
聚酯是可生物降解的多肽类似物，但由于缺乏分析溶液状态聚酯构象的方法，其生化应用受到阻碍。通过对聚L-乳酸(PLLA)、PLLA-直链淀粉复合物和低聚(L-乳酸)的研究，证明振动圆二色性(VCD)光谱可以方便、准确地阐明聚酯的构象。这些分子的VCD激子对分析阐明了PLLA稳定的左手螺旋结构，而寡聚(L-乳酸)的密度泛函理论计算揭示了其详细的结构性质。
Polyesters are biodegradable analogues of polypeptides, but their biochemical applications have been hampered by the lack of a method to analyze polyester conformation in a solution state. We have demonstrated that vibrational circular dichroism (VCD) spectroscopy can conveniently and accurately elucidate the conformation of polyesters through the studies on poly(L-lactic acid) (PLLA), PLLA-amylose complex, and oligo(L-lactic acid). The analysis of VCD exciton couplet of these molecules has clarified the stable left-handed helical structure of PLLA, while density functional theory calculations of oligo(L-lactic acid) have revealed its detailed structural nature.