Time Trends and the Influence of Age and Gender on Serum Concentrations of Perfluorinated Compounds in Archived Human Samples
Time Trends and the Influence of Age and Gender on Serum Concentrations of Perfluorinated Compounds in Archived Human Samples
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DOI：
10.1021/es802827u
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发表时间：
2009-03-15
影响因子：
11.4
通讯作者：
Bechert, Georg
中科院分区：
文献类型：
--
作者：
Haug, Line S.;Thomsen, Cathrine;Bechert, Georg
分析了57份合并存档的人类血清样本，以评估时间趋势以及年龄和性别对挪威居民中选定的全氟化合物（PFCs）的影响。该研究包括测定1976年至2007年期间28年收集的血清样本中的19种全氟化学品。从1977年到20世纪90年代中期，男性（40-50岁）的全氟辛基磺酸盐、全氟辛酸和全氟庚基磺酸盐的血清浓度增加了9倍，在2000年左右开始下降之前，浓度达到了一个平台。全氟己基磺酸盐、全氟壬酸、全氟癸酸和全氟十一烷酸也出现了类似的趋势，但近年来这些全氟化学品没有出现明显的下降。雄性和雌性血清池中PFC水平之间未观察到统计学显著性差异，但由于数据点较少，统计学把握度较低。对于大多数全氟化学品，从2007年开始，人类血清样本中的浓度随着年龄的增长而增加，而1976年、1987年和1998年的结果差异更大。几个PFC显着相互关联。
Fifty-seven pooled archived human serum samples were analyzed to assess the time trends as well as influence of age and gender on selected perfluorinated compounds (PFCs) in Norwegian residents. The study comprised determinations of 19 PFCs in serum samples pooled according to year of collection from 28 years in the period 1976 to 2007. A 9-fold increase in the serum concentrations of perfluorooctyl sulfonate, perfluorooctanoic acid, and perfluoroheptyl sulfonate was measured for men (40-50 years) from 1977 to the mid 1990s where the concentrations reached a plateau before starting to decrease around year 2000. A similar trend was also seen for perfluorohexyl sulfonate, perfluorononanoic acid, perfluorodecanoic acid, and perfluoroundecanoic acid, but no clear decline was observed for these PFCs in the recent years. No statistically significant difference was observed between the PFC levels in the male and female serum pools, though the statistical power is low due to few data points. For most PFCs, the concentrations in the human serum samples were found to increase with age in the pools from 2007, while the results for 1976, 1987, and 1998 were more varying. Several PFCs were significantly intercorrelated.