Modelling and experimental investigation of capsule-tumour contact for early bowel cancer detection
Modelling and experimental investigation of capsule-tumour contact for early bowel cancer detection
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DOI：
10.1016/j.euromechsol.2023.105148
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发表时间：
2023-10-05
影响因子：
4.1
通讯作者：
Liu，Caishan
中科院分区：
文献类型：
--
作者：
Tian，Jiyuan;Liu，Yang;Liu，Caishan
组织的机械特性，如硬度，是关键的生物标记物，可以用来检测恶变的早期阶段，并区分健康和异常组织。本文研究了一种利用胶囊机器人评估肠道肿瘤硬度的新方法，用于肠癌的早期检测和分期。赫兹接触理论被用来模拟肠道环境中的包膜-肿瘤接触。侧向接触和垂直接触均采用有限元分析和实验验证。将所提出的模型得到的肠肿瘤的杨氏模数应用于有限元模型，然后生成力-位移曲线，以与实验进行比较。对比分析表明，有限元计算结果与实验结果吻合较好。该方法可用于通过胶囊机器人在肠道内自动推进来实时检测早期肠癌。
Tissue’s mechanical properties, such as stiffness, are critical biomarkers that could be utilised to detect early stages of malignant transformation and distinguish between healthy and abnormal tissues. This paper studied a new method by using a capsule robot to evaluate the stiffness of bowel tumour for early bowel cancer detection and staging. Hertz contact theory was used to model capsule-tumour contact in an intestinal environment. Both lateral and vertical contacts were performed with finite element (FE) and experimental validations. Young’s moduli of bowel tumours obtained by the proposed models were applied to FE models and then generated force–displacement curves to compare with experiments. Our comparative analyses show that FE results are in good agreement with experimental results. The proposed method can be potentially used in real time for detecting early bowel cancer by using a capsule robot when self-propelling in the bowel.