The characteristics of HIV-positive patients with mild/asymptomatic and moderate/severe course of COVID-19 disease-A report from Central and Eastern Europe.
The characteristics of HIV-positive patients with mild/asymptomatic and moderate/severe course of COVID-19 disease-A report from Central and Eastern Europe.
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轻/无症状和中/重度新冠肺炎病程的艾滋病毒阳性患者的特征-来自中欧和东欧的报告。
DOI：
10.1016/j.ijid.2020.12.026
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Matulionyte R
中科院分区：
文献类型：
--
作者：
Kowalska JD;Kase K;Vassilenko A;Harxhi A;Lakatos B;Lukić GD;Verhaz A;Yancheva N;Dumitrescu F;Jilich D;Machala L;Skrzat-Klapaczyńska A;Matulionyte R
目前没有证据表明，与普通人群相比，接受抗逆转录病毒治疗的 HIV 阳性患者的 COVID-19 病程有所不同。然而，人们对特定 HIV 相关因素与 COVID-19 疾病严重程度之间的关系知之甚少。我们对通过中东欧欧洲指南网络集团分发的在线调查收集的病例进行了回顾性分析。在统计分析艾滋病毒阳性患者的特征时，比较了无症状/中度和中度/重度病程。 12 个国家（爱沙尼亚、捷克共和国、立陶宛、阿尔巴尼亚、白俄罗斯、罗马尼亚、塞尔维亚、波斯尼亚和黑塞哥维那、波兰、俄罗斯、匈牙利、保加利亚）报告了总共 34 名 HIV 阳性患者被诊断为 COVID-19。 4 例 (12%) 病例报告了无症状的 COVID-19 病程，11 例 (32%) 例患者出现不需要住院的轻度疾病，14 例 (41%) 例患者出现呼吸系统和/或全身症状的中度疾病，5 例 (15%) 例患者出现呼吸衰竭的严重疾病。除 cART 方案中使用非核苷逆转录酶抑制剂 (NNRTI) 外，无症状/轻度 COVID-19 病程患者的 HIV 相关特征与中度/重度 COVID-19 病程患者相当（分别为 0.0% 和 31.6%，p = 0.0239）。在我们的分析中，HIV 病毒抑制和免疫状态与 COVID-19 病程无关。相反，cART 方案可能会加剧 SARS-CoV-2 感染的严重程度。有必要进行大型前瞻性研究来进一步研究这种关系。
There is currently no evidence suggesting that COVID-19 takes a different course in HIV-positive patients on antiretroviral treatment compared to the general population. However, little is known about the relation between specific HIV-related factors and the severity of the COVID-19 disease. We performed a retrospective analysis of cases collected through an on-line survey distributed by the Euroguidelines in Central and Eastern Europe Network Group. In statistical analyses characteristics of HIV-positive patients, asymptomatic/moderate and moderate/severe course were compared. In total 34 HIV-positive patients diagnosed with COVID-19 were reported by 12 countries (Estonia, Czech Republic, Lithuania, Albania, Belarus, Romania, Serbia, Bosnia and Herzegovina, Poland, Russia, Hungary, Bulgaria). Asymptomatic courses of COVID-19 were reported in four (12%) cases, 11 (32%) patients presented with mild disease not requiring hospitalization, moderate disease with respiratory and/or systemic symptoms was observed in 14 (41%) cases, and severe disease with respiratory failure was found in five (15%) patients. The HIV-related characteristics of patients with an asymptomatic/mild course of COVID-19 were comparable to those with a moderate/severe course of COVID-19, except for the use of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in cART regimen (0.0% vs. 31.6% respectively, p = 0.0239). In our analyses HIV viral suppression and immunological status were not associated with the course of COVID-19 disease. On the contrary the cART regimen could contribute to severity of SARS-CoV-2 infection. Large and prospective studies are necessary to further investigate this relationship.
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