Cell-matrix adhesion in vascular development
Cell-matrix adhesion in vascular development
复制标题
DOI：
10.1111/j.1538-7836.2007.02569.x
复制
发表时间：
2007-07-01
影响因子：
10.4
通讯作者：
Hynes, R. O.
中科院分区：
文献类型：
--
作者：
Hynes, R. O.
血管发育需要内皮细胞、周细胞和周围细胞之间正确的相互作用。这些相互作用涉及许多细胞黏附相互作用，包括与基底膜和周围细胞外基质的细胞-基质相互作用。在过去的10-15年里，对这些不同的相互作用在血管发育和血管生成中的贡献的研究一直是相当不均衡和不完整的。已有相当多的研究集中在少数受体、基质蛋白和蛋白水解性片段上，目的是找到控制血管生成的方法。许多其他潜在的贡献者受到的关注要少得多。即使对于那些受到密集研究的分子，我们的知识也是不完整的。本文综述了可能促进血管生成的细胞外基质(ECM)蛋白和细胞-基质黏附受体(尤其是整合素)的光谱，并讨论了它们各自的已知和未知的作用。
Vascular development requires correct interactions among endothelial cells, pericytes and surrounding cells. These interactions involve many cell adhesion interactions, including cell-matrix interactions both with basement membranes and with surrounding extracellular matrices. Investigations of the contributions of these various interactions in vascular development and angiogenesis have been rather uneven and incomplete over the past 10-15 years. There has been considerable concentration on a few receptors, matrix proteins and proteolytic fragments with the goal of finding means to control angiogenesis. Many other potential contributors have received much less attention. Even for those molecules that have been subject to intensive investigation, our knowledge is incomplete. This review will survey the spectrum of extracellular matrix (ECM) proteins and cell-matrix adhesion receptors (particularly integrins) that are likely to contribute to angiogenesis and discuss what is known and not known about the roles of each of them.