Herpes zoster: Family history and psychological stress-Case-control study
Herpes zoster: Family history and psychological stress-Case-control study
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DOI：
10.1016/j.jcv.2012.06.020
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发表时间：
2012-10-01
影响因子：
8.8
通讯作者：
Hanslik, Thomas
中科院分区：
文献类型：
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作者：
Lasserre, Andrea;Blaizeau, Fanette;Hanslik, Thomas
背景：几项研究报告了带状疱疹 (HZ) 的危险因素，但由于抽样和设计方面的局限性，其结果仍然存在争议且难以比较。 目的：本研究旨在通过咨询法国全科医生 (GP) 来确定 50 岁或以上的门诊患者的危险因素。 研究设计： 进行了一项前瞻性、全国性、匹配的病例对照研究。该研究涉及 121 名全科医生，他们在 2009 年 4 月至 2010 年 9 月期间招募了 250 名带状疱疹病例和 500 名 50 岁及以上的对照组（按年龄和性别匹配）。全科医生和患者问卷调查探讨了以下危险因素：带状疱疹家族史、合并症、抑郁、焦虑、负面生活事件、身体创伤、饮酒和吸烟、教育水平以及各种保护因素（例如与儿童接触）。使用条件逻辑回归估计优势比。结果：在多变量调整分析中，HZ 家族史（OR 3.69，95% CI 1.81-7.51）、HAD 抑郁评分 >= 8（OR 4.15，95% CI 1.88-9.16）和近期负面生活事件（OR 3.40，95% CI 1.67-6.93）均与显着相关 HZ.结论：这项在全科门诊患者中进行的病例对照研究强化了这样的假设：除了 VZV 特异性 T 细胞介导的免疫力与年龄相关的下降之外，抑郁阴性生活事件和熟悉的带状疱疹病史也会增加带状疱疹发生的风险。对于有熟悉病史的人来说，这种风险可以通过疫苗接种来预防。 (C) 2012 Elsevier B.V. 保留所有权利。
Background: Several studies have reported risk factors for herpes zoster (HZ), but their results remain controversial and difficult to compare because of their limitations regarding sampling and design.Objectives: This study was aimed to determine risk factors in ambulatory patients aged 50 years or more, by consulting general practitioners (GPs) in France.Study design: A prospective, national, matched case-control study was conducted. It involved 121 GPs who recruited 250 cases of HZ and 500 controls (matched by age and sex), aged 50 years and older, between April 2009 and September 2010. GP and patient questionnaires explored the following risk factors: family history of HZ, comorbidities, depression, anxiety, negative life events, physical trauma, alcohol and tobacco consumption, level of education, and various protective factors (such as exposure to children). Odds ratios were estimated using conditional logistic regression.Results: In multivariate adjusted analysis, a family history of HZ (OR 3.69, 95% CI 1.81-7.51), a HAD depressive score >= 8 (OR 4.15, 95% CI 1.88-9.16), and a recent negative life event (OR 3.40, 95% CI 1.67-6.93) were all significantly associated with HZ.Conclusions: This case-control study conducted in ambulatory patients in general practice reinforced the hypothesis that, in addition to the age-related decline in VZV-specific T-cell-mediated immunity, depression negative life event and familiar history of zoster increase the risk of occurrence of herpes zoster. In people with familiar history, this risk could be prevented by vaccination. (C) 2012 Elsevier B. V. All rights reserved.