Use of Stimulan absorbable calcium sulphate beads in revision lower limb arthroplasty: Safety profile and complication rates.
Use of Stimulan absorbable calcium sulphate beads in revision lower limb arthroplasty: Safety profile and complication rates.
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DOI：
10.1302/2046-3758.710.bjr-2017-0319.r1
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发表时间：
2018-10
影响因子：
4.6
通讯作者：
McPherson E
中科院分区：
文献类型：
--
作者：
Kallala R;Harris WE;Ibrahim M;Dipane M;McPherson E
传统上，硫酸钙被用来填充手术中产生的死腔。在使用Stimulan生物可吸收硫酸钙珠后，已经描述了各种并发症。这项研究是一项前瞻性的观察性研究，旨在评估这些珠子用于翻修关节成形术时的安全性，并与文献报道的并发症发生率进行比较。共有755名患者接受了456例翻修全膝关节置换术(TKA)和299例翻修全髋关节置换术(THA)，平均随访35个月(0~78个月)。共有32名患者(4.2%)有伤口引流，这一比例在珠子体积较大的患者和McFherson C级患者中更高。在41名出现高钙血症的患者中，珠子体积也显著增加，其中两人有症状(p<；0.0001)。异位骨化13例(1.7%)。HO的发展与珠子体积之间没有统计学意义的关系(p>；0.05)。这项研究的优势在于大量的患者和详细的数据收集，使其成为文献中关于以硫酸钙为基础的骨替代品使用情况的最全面的报告。引用本文：R.Kallala，W.Edwin Harris，M.Ibrahim，M.Dipane，E.McPherson。Stimulan可吸收硫酸钙珠在翻修下肢关节置换术中的应用：安全性和并发症发生率。骨关节分辨率2018；7：570-579。DOI：10.1302/2046-3758.710.BJR-2017-0319.R1.
Calcium sulphate has traditionally been used as a filler of dead space arising during surgery. Various complications have been described following the use of Stimulan bio-absorbable calcium sulphate beads. This study is a prospective observational study to assess the safety profile of these beads when used in revision arthroplasty, comparing the complication rates with those reported in the literature. A total of 755 patients who underwent 456 revision total knee arthroplasties (TKA) and 299 revision total hip arthroplasties (THA), with a mean follow-up of 35 months (0 to 78) were included in the study. A total of 32 patients (4.2%) had wound drainage, and this was higher with higher bead volumes and in McPherson grade C patients. There was also a significantly higher bead volume in the 41 patients who developed hypercalcaemia, two of which were symptomatic (p < 0.0001). A total of 13 patients (1.7%) had heterotopic ossification (HO). There was no statistically significant relationship between the development of HO and bead volume (p > 0.05). The strength of this study lies in the large number of patients and the detailed data collection, making it the most comprehensive report available in the literature on the use of calcium sulphate-based bone substitutes. Cite this article: R. Kallala, W. Edwin Harris, M. Ibrahim, M. Dipane, E. McPherson. Use of Stimulan absorbable calcium sulphate beads in revision lower limb arthroplasty: Safety profile and complication rates. Bone Joint Res 2018;7:570–579. DOI: 10.1302/2046-3758.710.BJR-2017-0319.R1.