The DELLA Protein SLR1 Integrates and Amplifies Salicylic Acid- and Jasmonic Acid-Dependent Innate Immunity in Rice
The DELLA Protein SLR1 Integrates and Amplifies Salicylic Acid- and Jasmonic Acid-Dependent Innate Immunity in Rice
复制标题
DOI：
10.1104/pp.15.01515
复制
发表时间：
2016-03-01
期刊：
影响因子：
7.4
通讯作者：
Hofte, Monica
中科院分区：
文献类型：
--
作者：
De Vleesschauwer, David;Seifi, Hamed Soren;Hofte, Monica
赤霉素是一类四环植物激素，众所周知其通过诱导一类称为DELLA的核生长抑制蛋白的降解来促进植物生长。近年来，GA和DELLA也越来越多地参与植物对病原体攻击的反应，尽管我们对潜在机制的理解仍然有限，特别是在单子叶作物植物中。为了进一步破译GA和DELLA调节植物免疫的分子基础，我们研究了GA和DELLA在感染模式作物水稻（Oryza sativa）的过程中的动态和影响，其中四种不同的病原体表现出不同的生活方式和感染策略。相反，以前的研究结果在拟南芥（拟南芥），我们的研究结果揭示了一个突出的作用DELLA蛋白细长水稻1（SLR1）对（半）活体营养型水稻病原体的阻力，但不是坏死营养型。此外，与DELLA对拟南芥中原型防御激素水杨酸（SA）和茉莉酸（JA）的差异效应相反，我们证明SLR1的抗性促进效应至少部分是由于其能够增强SA和JA介导的水稻防御。以相互的方式，我们发现JA和SA处理干扰GA代谢和稳定SLR1。总之，这些研究结果有利于一个模型，SLR1作为一个积极的调节剂，在水稻中的半生物营养抗性的整合和放大SA和JA依赖的防御信号。我们的结果强调了水稻和拟南芥之间激素防御网络的差异，并强调了GA和DELLA在塑造疾病结果中的重要性。
Gibberellins are a class of tetracyclic plant hormones that are well known to promote plant growth by inducing the degradation of a class of nuclear growth-repressing proteins, called DELLAs. In recent years, GA and DELLAs are also increasingly implicated in plant responses to pathogen attack, although our understanding of the underlying mechanisms is still limited, especially in monocotyledonous crop plants. Aiming to further decipher the molecular underpinnings of GA- and DELLA-modulated plant immunity, we studied the dynamics and impact of GA and DELLA during infection of the model crop rice (Oryza sativa) with four different pathogens exhibiting distinct lifestyles and infection strategies. Opposite to previous findings in Arabidopsis (Arabidopsis thaliana), our findings reveal a prominent role of the DELLA protein Slender Rice1 (SLR1) in the resistance toward (hemi) biotrophic but not necrotrophic rice pathogens. Moreover, contrary to the differential effect of DELLA on the archetypal defense hormones salicylic acid (SA) and jasmonic acid (JA) in Arabidopsis, we demonstrate that the resistance-promoting effect of SLR1 is due at least in part to its ability to boost both SA-and JA-mediated rice defenses. In a reciprocal manner, we found JA and SA treatment to interfere with GA metabolism and stabilize SLR1. Together, these findings favor a model whereby SLR1 acts as a positive regulator of hemibiotroph resistance in rice by integrating and amplifying SA- and JA-dependent defense signaling. Our results highlight the differences in hormone defense networking between rice and Arabidopsis and underscore the importance of GA and DELLA in molding disease outcomes.