Systems Scale Interactive Exploration Reveals Quantitative and Qualitative Differences in Response to Influenza and Pneumococcal Vaccines
Systems Scale Interactive Exploration Reveals Quantitative and Qualitative Differences in Response to Influenza and Pneumococcal Vaccines
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DOI：
10.1016/j.immuni.2012.12.008
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发表时间：
2013-04-18
期刊：
影响因子：
32.4
通讯作者：
Chaussabel, Damien
中科院分区：
文献类型：
--
作者：
Obermoser, Gerlinde;Presnell, Scott;Chaussabel, Damien
采用系统免疫学方法来研究对流感和肺炎球菌疫苗的先天和适应性免疫反应。这两种非活疫苗在疫苗接种后的不同时间点显示出不同的转录响应幅度。开发了软件解决方案，以探索在第28天测量为抗体滴度的疫苗功效的相关性。这些抗体效应使得进一步解剖了转录响应。因此，在流感疫苗接种后的干扰素转录特征和肺炎球菌疫苗接种后的炎症特征之后，在数小时内的天生反应以干扰素转录特征为主。两种疫苗诱导的第7天的浆膜反应在肺炎球菌疫苗接种后更为明显。总之，这些结果表明，比较不同疫苗引起的全球免疫反应对于我们对成功疫苗接种的免疫机制的理解至关重要。
Systems immunology approaches were employed to investigate innate and adaptive immune responses to influenza and pneumococcal vaccines. These two non-live vaccines show different magnitudes of transcriptional responses at different time points after vaccination. Software solutions were developed to explore correlates of vaccine efficacy measured as antibody titers at day 28. These enabled a further dissection of transcriptional responses. Thus, the innate response, measured within hours in the peripheral blood, was dominated by an interferon transcriptional signature after influenza vaccination and by an inflammation signature after pneumococcal vaccination. Day 7 plasmablast responses induced by both vaccines was more pronounced after pneumococcal vaccination. Together, these results suggest that comparing global immune responses elicited by different vaccines will be critical to our understanding of the immune mechanisms underpinning successful vaccination.