Brain metabolism in hypothyroidism studied with 31P magnetic-resonance spectroscopy.
Brain metabolism in hypothyroidism studied with 31P magnetic-resonance spectroscopy.
复制标题
使用 31P 磁共振波谱研究甲状腺功能减退症的脑代谢。
DOI：
10.1016/s0140-6736(95)90522-7
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Ain,KB
中科院分区：
文献类型：
--
作者：
Smith,CD;Ain,KB
Metabolic consequences of hypothyroidism in adult human brain, despite neuropsychological symptoms, have not been reported. We used31P nuclear magnetic-resonance spectroscopy of the frontal lobe to examine the effect of acute hypothyroidism on cerebral metabolism. Paired analysis showed that the phosphocreatine/inorganic- phosphate (PCr/Pi) ratio increased from a median of 2·04 (interquartile range 0·15) to 2·22 (0·25) after treatment with levothyroxine (p=0·01). These reversible alterations in adult cerebral phosphate metabolism during acute hypothyroidism parallel PCr/Pi ratio changes described in skeletal muscle. This is the first direct evidence of cerebral metabolic effects of hypothyroidism on adult brain.
