Phylogeny of the TRAF/MATH domain.
Phylogeny of the TRAF/MATH domain.
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DOI：
10.1007/978-0-387-70630-6_1
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发表时间：
2007
影响因子：
--
通讯作者：
J. Zapata;Vanesa Martínez-García;S. Lefebvre
中科院分区：
文献类型：
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作者：
J. Zapata;Vanesa Martínez-García;S. Lefebvre
tnf受体相关因子（TRAF）结构域（TD），也称为meprin和TRAF- c同源结构域（MATH），是参与蛋白质-蛋白质相互作用的7个反平行ß-螺旋的折叠。这种折叠在真核生物中广泛存在，它被发现与一组离散的蛋白质结构域有关。几乎所有包含TRAF/MATH结构域的蛋白家族似乎都参与蛋白质加工和泛素化的调控，这强烈表明在真核生物中TRAF/MATH结构域和某些蛋白质水解途径是平行进化的。我们所掌握的生物遗传和蛋白质组成信息数量有限，限制了进化中数学领域的范围和分析。然而，现有的信息使我们能够对TRAF/MATH领域的起源、分布和演变有一个粗略的了解，这将在本章中进行概述。
The TNF-receptor associated factor (TRAF) domain (TD), also known as the meprin and TRAF-C homology (MATH) domain is a fold of seven anti-parallel ß-helices that participates in protein-protein interactions. This fold is broadly represented among eukaryotes, where it is found associated with a discrete set of protein-domains. Virtually all protein families encompassing a TRAF/MATH domain seem to be involved in the regulation of protein processing and ubiquitination, strongly suggesting a parallel evolution of the TRAF/MATH domain and certain proteolysis pathways in eukaryotes.The restricted number of living organisms for which we have information of their genetic and protein make-up limits the scope and analysis of the MATH domain in evolution. However, the available information allows us to get a glimpse on the origins, distribution and evolution of the TRAF/MATH domain, which will be overviewed in this chapter.