The Suppressive Effects of Lanthanum on the Production of Inflammatory Mediators in Mice Challenged by LPS
The Suppressive Effects of Lanthanum on the Production of Inflammatory Mediators in Mice Challenged by LPS
复制标题
镧对 LPS 小鼠炎症介质产生的抑制作用
DOI：
10.1007/s12011-010-8792-0
复制
发表时间：
2011-09-01
影响因子：
3.9
通讯作者：
Wang, Yang
中科院分区：
文献类型：
--
作者：
Guo, Fei;Guo, Xiang;Wang, Yang
稀土离子已被证明具有多种生物效应。镧具有极强的物理化学性质，具有抗菌和免疫调节作用。本研究观察了氯化镧(LaCl3)对内毒素(LPS)攻击小鼠的体内和体外抗炎作用。结果表明，LaCl3能显著降低脂多糖诱导的小鼠肿瘤坏死因子-α和白介素1-β的分泌及肿瘤坏死因子-α的mRNA表达。为了阐明LaCl3对肝脏和腹膜巨噬细胞核因子-kappaB活化的影响，我们研究了LaCl3对肝脏和腹膜巨噬细胞核因子-kappaB活化的影响。LaCl3可显著阻断内毒素诱导的核因子-kappaB的激活。这些结果表明，LaCl3抑制内毒素诱导的炎症介质，如肿瘤坏死因子-α和白介素1-β，是由于抑制了核因子-kappaB的激活。
Lanthanide ions have been proven to have various biologic effects. Lanthanum with extremely active physical and chemical property was evidenced to possess antibacterial and immune adjustment effects. In the present study, the anti-inflammatory effects of lanthanum chloride (LaCl3) on lipopolysaccharide (LPS)-challenged mice were examined in vivo and in vitro. The results indicated that LaCl3 can greatly decrease the secretion of tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-1 beta as well as TNF-alpha mRNA expression in the mice challenged with LPS. To clarify the mechanism involved, the effects of LaCl3 on the activation of nuclear factor (NF)-kappa B were examined both in liver and in peritoneal macrophages. The LPS-induced activation of NF-kappa B was significantly blocked by LaCl3. These findings demonstrate that the inhibition of the LPS-induced inflammatory media, such as TNF-alpha and IL-1 beta, by LaCl3, is due to the inhibition of NF-kappa B activation.