Contingency management to enhance naltrexone treatment of opioid dependence: A randomized clinical trial of reinforcement magnitude
Contingency management to enhance naltrexone treatment of opioid dependence: A randomized clinical trial of reinforcement magnitude
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DOI：
10.1037//1064-1297.10.1.54
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发表时间：
2002-02-01
影响因子：
2.3
通讯作者：
Rounsaville, BJ
中科院分区：
文献类型：
--
作者：
Carroll, KM;Sinha, R;Rounsaville, BJ
55名脱毒阿片类药物依赖者被随机分配到12周内提供的3种治疗中的一种：标准纳洛酮维持，标准纳洛酮加低值应急管理（CM）或标准纳洛酮加高值CM。结果表明，（a）与标准纳洛酮治疗相比，分配到任何一种CM条件与阿片类药物使用随时间的显著减少相关;（B）高与低值强化幅度的对比不显著，表明在该人群中，高价值激励与低值激励没有相对益处;（c）与分配到标准纳洛酮治疗组的参与者相比，分配到CM组的参与者报告了改变准备程度的显著降低。这些研究结果表明，有针对性的行为疗法可以在扩大现有药物治疗的效用方面发挥重要作用。
Fifty-five detoxified opioid-dependent individuals were randomly assigned to I of 3 treatments delivered over 12 weeks: standard naltrexone maintenance, standard naltrexone plus low-value contingency management (CM), or standard naltrexone plus high-value CM. Results suggest that (a) assignment to either CM condition was associated with significant reductions in opioid use over time compared with standard naltrexone treatment; (b) contrasts of high- versus low-value reinforcement magnitude were not significant, suggesting no relative benefit of higher over lower value incentives in this population; (c) participants assigned to either CM group reported significant reductions in readiness to change compared with participants assigned to standard naltrexone treatment. These findings suggest that targeted behavioral therapies can play a substantial role in broadening the utility of available pharmacotherapies.