Ag(I)-Catalyzed [3+2]-Annulation of Cyclopropenones and Formamides via C-C Bond Cleavage
Ag(I)-Catalyzed [3+2]-Annulation of Cyclopropenones and Formamides via C-C Bond Cleavage
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Ag(I) 催化的 [3 2]-环丙烯酮和甲酰胺通过 C−C 键断裂成环
DOI：
10.1021/acs.orglett.8b02612
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发表时间：
2018-11-02
期刊：
影响因子：
5.2
通讯作者：
Sun, Meng
中科院分区：
文献类型：
--
作者：
Ren, Jiang-Tao;Wang, Jia-Xin;Sun, Meng
公开了前所未有的银催化的环丙烯酮和DMF通过C-C键断裂的[3 + 2]-成环。该方案表现出优异的化学和区域选择性，并耐受各种官能团。更重要的是，DMF作为环加成反应中的C=O键，提供了一种有效的方法来构建γ-氨基丁烯内酯。此外，当DMF被酯取代时，发生酯交换反应。
An unprecedented Ag-catalyzed [3 + 2]-annulation of cyclopropenones and DMF via C-C bond cleavage is disclosed. This protocol exhibited excellent chemo- and regio-selectivity, and tolerated various functional groups. More importantly, DMF served as the C=O bond in the cycloaddition reaction, providing an efficient way to construct gamma-aminobutenolides. In addition, transesterification reaction occurred when DMF was replaced by esters.