Time window of infarct reduction by intravenous basic fibroblast growth factor in focal cerebral ischemia.
Time window of infarct reduction by intravenous basic fibroblast growth factor in focal cerebral ischemia.
复制标题
局灶性脑缺血中静脉注射碱性成纤维细胞生长因子减少梗塞的时间窗。
DOI：
10.1016/s0014-2999(97)89672-0
复制
发表时间：
1997
影响因子：
5
通讯作者：
Finklestein,SP
中科院分区：
文献类型：
--
作者：
Ren,JM;Finklestein,SP
碱性成纤维细胞生长因子 (bFGF) 是一种肝素结合多肽，对脑神经元、神经胶质细胞和内皮细胞具有有效的营养和保护作用。在之前的研究中，我们发现静脉注射 bFGF 可减少大鼠大脑中动脉永久闭塞后的脑梗塞体积。在当前的研究中，我们检查了 bFGF 输注对梗塞减少的时间依赖性，以及 bFGF 与肝素共同输注的效果。我们发现，当 bFGF 输注（50 μg/kg/h，持续 3 小时）在缺血发生后 3 小时（而非 4 小时）开始时，梗塞体积显着减少。 bFGF 的梗塞减少作用并未因肝素的共同输注而改变。鉴于正在进行的静脉bFGF治疗急性中风的临床试验，这些结果可能很重要。
Basic fibroblast growth factor (bFGF) is a heparin-binding polypeptide with potent trophic and protective effects on brain neurons, glia and endothelia. In previous studies, we showed that intravenously administered bFGF reduced the volume of cerebral infarcts following permanent occlusion of the middle cerebral artery in rats. In the current study, we examined the time dependence of bFGF infusion on infarct reduction, and the effect of co-infusion of bFGF with heparin. We found a significant reduction in infarct volume when the bFGF infusion (50 μg/kg per h for 3 h) was begun up to 3 h, but not 4 h after the onset of ischemia. The infarct reducing effects of bFGF were not altered by co-infusion of heparin. These results are potentially important in light of the ongoing clinical trials of intravenous bFGF in acute stroke.