Molecular regulation of the intestinal epithelial barrier: implication in human diseases.
Molecular regulation of the intestinal epithelial barrier: implication in human diseases.
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DOI：
10.2741/3888
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发表时间：
2011-06
期刊：
影响因子：
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通讯作者：
Zhihua Liu;Chen-zhang Shi;Jian-jun Yang;Peng Zhang;Yanlei Ma;Feng Wang;H. Qin
中科院分区：
文献类型：
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作者：
Zhihua Liu;Chen-zhang Shi;Jian-jun Yang;Peng Zhang;Yanlei Ma;Feng Wang;H. Qin
肠屏障功能障碍与各种临床疾病的发展有关。虽然肠道屏障功能的研究传统上强调肠道微生物菌群和细菌的影响，但分子和细胞技术的快速发展有助于该领域最近向肠道上皮屏障的分子调节过渡。本文从益生菌等外源性因素、紧密连接蛋白、肠碱性磷酸酶和蛋白磷酸酶2A等内源性蛋白质效应物、肠上皮内淋巴细胞和肠干细胞等肠上皮细胞亚群等方面综述了近年来肠上皮屏障的分子调控研究进展。对肠上皮屏障分子调控机制的进一步研究将使我们能够操纵相关的因子和细胞亚群，以开发治疗肠屏障功能障碍相关疾病的有效方法。
Intestinal barrier dysfunction is implicated in the development of various clinical diseases. While the study of intestinal barrier function has traditionally emphasized the impact of intestinal microflora and bacteria, the rapid development of molecular and cellular techniques has helped the recent transition of the field to the molecular regulation of the intestinal epithelial barrier. In this review, we summarized several aspects of recent progress on the molecular regulation of the intestinal epithelial barrier, ranging from the extrinsic factors such as probiotics, intrinsic protein effectors including the tight junction proteins, intestinal alkaline phosphatase and protein phosphatase 2A, to intestinal cell subsets such as intestinal intraepithelial lymphocytes and intestinal stem cells. Further investigations into the detailed mechanisms underlying the molecular regulation of the intestinal epithelial barrier will enable our manipulation of the factors and cell subsets involved to develop effective approaches to treat intestinal barrier dysfunction associated diseases.