The D P Wilson Lecture. Research on settlement and metamorphosis of marine invertebrate larvae: Past, present and future
The D P Wilson Lecture. Research on settlement and metamorphosis of marine invertebrate larvae: Past, present and future
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DOI：
10.1080/08927019809378343
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发表时间：
1998-01-01
期刊：
影响因子：
2.7
通讯作者：
Hadfield, MG
中科院分区：
文献类型：
--
作者：
Hadfield, MG
1952年，D·P·威尔逊（D·P·Wilson）指出，无脊椎动物的幼虫，“......其实，他们并不无助，因为他们被赋予了选择的权力，“在定居点。随后的努力极大地提高了对幼虫变态条件的理解，将这一过程的概念观点从“幼虫选择”转变为“发育诱导”，并将无脊椎动物变态的研究与现代发育生物学的研究相结合。虽然大多数变态诱导剂的精确化学性质回避我们，阐明的现象，接收和转导似乎迫在眉睫的许多幼虫。诱导物质的受体细胞和分子特异性的证据是令人信服的幼虫在几个门，和一个概括的图片刺激的电兴奋细胞已经出现;幼虫从至少八个无脊椎动物门变态反应增强K+。要确定的是指定受体蛋白质的基因是否变态诱导共享同源性，以及是否变态信号转导相同的细胞内途径跨无脊椎动物门。变态能力可能是一种发育上独特的条件，在这种条件下，不生长、不进食的幼虫在收到信号时就开始变态;对能力的遗传解释值得深入探索。海洋无脊椎动物幼虫的知识收购可比的遗传基础的光响应和蛹羽化的时间在果蝇将提供材料，令人兴奋的研究在未来几年。许多物种（如多毛类Hydroides elegans）为无脊椎动物定居和变态的实验室遗传学研究提供了极好的模型。
In 1952, D P Wilson remarked that invertebrate larvae, "...are indeed not helpless, for they are endowed with the power of choice,..." at settlement. Subsequent efforts have greatly enhanced understanding of the conditions under which larvae metamorphose, altering the conceptual view of this process from "larval choice" to "developmental induction," and aligning studies of invertebrate metamorphosis with those of modern developmental biology. While the precise chemical nature of most metamorphic inducers evades us, elucidation of the phenomena of reception and transduction appears imminent for many larvae. The evidence for receptor cells and molecules specific for inducer substances is convincing for larvae in several phyla, and a generalized picture of stimulation of electrically excitable cells has emerged; larvae from al least eight invertebrate phyla metamorphose in response to augmented K+. To be determined is whether genes specifying receptor proteins for metamorphic inducers share homology and whether metamorphic signals are transduced by the same intracellular pathways across invertebrate phyla. Metamorphic competence can be a developmentally unique condition where non-growing, non-feeding larvae are primed to metamorphose when signaled; a genetic explanation for competence merits intense exploration. The acquisition for marine invertebrate larvae of knowledge comparable to that for the genetic basis of timing of photic responses and pupal eclosion in Drosophila will provide material for exciting research in the years ahead. Many species (e.g. the polychaete Hydroides elegans) offer excellent models for laboratory genetic studies of invertebrate settlement and metamorphosis.